Semiquantitative perfusion combined with diffusion-weighted MR imaging in pre-operative evaluation of endometrial carcinoma: Results in a group of 57 patients

• Published in: Magnetic resonance imaging 2014-06, Vol.32 (5), p.464-472
• Main Authors: Ippolito, Davide, Cadonici, Anna, Bonaffini, Pietro Andrea, Minutolo, Orazio, Casiraghi, Alessandra, Perego, Patrizia, Sironi, Sandro
• Format: Article
• Language: English
• Subjects: Algorithms; Diffusion Magnetic Resonance Imaging - methods; Endometrial cancer; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Magnetic Resonance Angiography - methods; Magnetic resonance imaging; Middle Aged; Multimodal Imaging - methods; Observer Variation; Patient Selection; Pattern Recognition, Automated - methods; Perfusion imaging; Preoperative Care - methods; Prognosis; Radiology; Reproducibility of Results; Sensitivity and Specificity; Staging; T1 contrast sequences
• ISSN: 0730-725X; 1873-5894
• DOI: 10.1016/j.mri.2014.01.009

Abstract Purpose To evaluate the semiquantitative DCE and quantitative DWI parameters in endometrial cancer, in order to assess the presence of neoplastic tissue and normal myometrium and to ascertain a potential relationship with tumor grade. Methods and materials A total of 57 patients with biopsy-proven endometrial adenocarcinoma who underwent MR imaging examination for staging purposes were retrospectively evaluated. Imaging protocol included multiplanar T1 - and T2 -weighted TSE, DCE T1 -weighted (THRIVE; 0, 30, 90 and 120 seconds after intravenous injection of gadolinium) and DWIBS sequences ( b values = 0 and 1000 mm2 /s). Color perfusion and ADC maps were automatically generated on dedicated software. Relative enhancement (RE, %), maximum enhancement (ME, %), maximum relative enhancement (MRE, %), time to peak (TTP, s) and mean apparent diffusion coefficient (ADC) were calculated by manually drawing a region of interest (ROI) both on the neoplastic tissue and the normal myometrium. Histopathology was used as reference standard. Results Histopathological analysis confirmed the presence of endometrial carcinoma in all patients. Neoplastic tissue demonstrated significantly lower ( P < 0.001) values of RE (%) 63.92 ± 35.68; ME (%) 864.91 ± 429.54 and MRE (%) 75.97 ± 38.26 as compared to normal myometrium (RE (%) 151.43 ± 55.99; ME (%) 1800.73 ± 721.32; MRE (%) 158.28 ± 54.05). TTP was significantly higher ( P < 0.05) in tumor lesion (385.51 ± 1630.27 vs 195.44 ± 78.69). Mean ADC value of neoplastic tissue (775.09 ± ?220.73 × 10 − 3 mm2 /s) was significantly lower ( P < 0.05) than in myometrium (1602.37 ± 378.54 × 10 − 3 mm2 /s). The analysis of perfusion and diffusion parameters classified according to tumor grades, showed a statistically significant difference only for RE ( P = 0.043) and ME ( P = 0.007). Conclusions Perfusion parameters and mean ADC differ significantly between endometrial cancer and normal myometrium, potentially reflecting the different microscopical features of cellularity and vascularity; however a significant relationship with tumor grade was not found in our series.