Calpain system dysregulation in rat brain at beta-amyloid-induced neurodegeneration

Experimental evidence of calcium-dependent proteolysis dysregulation in brain of the murine model of Alzheimer’s disease was obtained. Experimental treatment, consisting of intra-hippocampal injection of amyloid beta-peptide (Aβ 1–40 ), promoted activation of main calpain forms in murine brain along...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2013-09, Vol.39 (5), p.510-515
Main Authors: Lysenko, L. A., Kantserova, N. P., Rendakov, N. L., Sel’verova, N. B., Nemova, N. N.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Organic Chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Experimental evidence of calcium-dependent proteolysis dysregulation in brain of the murine model of Alzheimer’s disease was obtained. Experimental treatment, consisting of intra-hippocampal injection of amyloid beta-peptide (Aβ 1–40 ), promoted activation of main calpain forms in murine brain along with a decrease in the content of a natural calpain inhibitor, calpastatin. As a result of a prognostic experiment on the correction of neurodegeneration induced in rats, neuroprotective properties of a steroid hormone estradiol were confirmed and a possible mechanism of the protective effect was suggested. The results allow consideration of both biochemical modifications in protein facilities of a pathology-affected brain and the mechanisms of neurodegeneration and neuroprotection.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162013050117