Breathing and brain state: Urethane anesthesia as a model for natural sleep

Highlights • Spontaneous brain state alternations occur under urethane anesthesia. • State alternations under urethane resemble the natural sleep cycle. • Respiratory characteristics are correlated with alternations of state. • Urethane is a useful model for natural sleep.

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2013-09, Vol.188 (3), p.324-332
Main Authors: Pagliardini, Silvia, Funk, Gregory D, Dickson, Clayton T
Format: Article
Language:English
Subjects:
Anesthesia
Anesthetics, Intravenous
Animals
Brain - drug effects
Brain - physiology
Electroencephalography - drug effects
Humans
Medical Education
Models, Biological
Pulmonary/Respiratory
REM sleep
Respiration - drug effects
Respiratory control
Respiratory Mechanics - drug effects
Respiratory Mechanics - physiology
Sleep - physiology
Sleep cycle
Slow-wave sleep
State alternation
Urethane
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Description
Summary:Highlights • Spontaneous brain state alternations occur under urethane anesthesia. • State alternations under urethane resemble the natural sleep cycle. • Respiratory characteristics are correlated with alternations of state. • Urethane is a useful model for natural sleep.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2013.05.035