Xiaoxuming decoction for acute ischemic stroke: A systematic review and meta-analysis

Xiaoxuming decoction (XXMD) is a well-known traditional Chinese herbal prescription in treatment of patients with stroke. The objective of this study is to assess the efficacy and safety of XXMD for acute ischemic stroke. A systematic literature search was conducted in 6 databases until June 2012 to...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2013-06, Vol.148 (1), p.1-13
Main Authors: Fu, Deng-lei, Lu, Lin, Zhu, Wenzong, Li, Ji-huang, Li, Hui-qin, Liu, Ai-ju, Xie, Chenglong, Zheng, Guo-qing
Format: Article
Language:English
Subjects:
Acute ischemic stroke
computer software
Drugs, Chinese Herbal - therapeutic use
health services
Humans
meta-analysis
National Institutes of Health
Oriental traditional medicine
patients
placebos
randomized clinical trials
recruitment
relative risk
safety assessment
stroke
Stroke - drug therapy
Systematic review
terminology
Treatment Outcome
Xiaoxuming decoction
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Summary:Xiaoxuming decoction (XXMD) is a well-known traditional Chinese herbal prescription in treatment of patients with stroke. The objective of this study is to assess the efficacy and safety of XXMD for acute ischemic stroke. A systematic literature search was conducted in 6 databases until June 2012 to identify randomized controlled trials (RCTs) of XXMD for acute ischemic stroke compared with western conventional medicine (WCM). The primary outcome measures were National Institutes of Health Stroke Scale (NIHSS) scores and modified Rankin Scale (mRS) scores. The secondary outcome measures were the clinical effective rate and adverse events at the end of treatment course. The methodological quality of RCTs was assessed independently using 12-item criteria according to the Cochrane Back Review Group. All data were analyzed using Review Manager 5.0 software. Eight RCTs with 601 individuals published from 1992 to 2012 were identified. The studies were deemed to have a high risk of bias. Compared with WCM, 1 RCT showed significant effects of XXMD for improving mRS after stroke (p
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2013.04.002