Modulation of affective symptoms and resting state activity by brain stimulation in a treatment-resistant case of obsessive-compulsive disorder

The effect of transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) on psychopathological symptoms and resting state brain activity was assessed in a patient with obsessive-compulsive disorder (OCD). tDCS and rTMS had no effect on OC symptoms. tDCS, h...

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Bibliographic Details
Published in:Neurocase 2013-08, Vol.19 (4), p.360-370
Main Authors: Volpato, C., Piccione, F., Cavinato, M., Duzzi, D., Schiff, S., Foscolo, L., Venneri, A.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affective Symptoms - etiology
Affective Symptoms - therapy
Anxiety disorders. Neuroses
Biological and medical sciences
Brain - physiology
Electric Stimulation Therapy - methods
fMRI
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Obsessive-Compulsive Disorder - complications
Obsessive-Compulsive Disorder - therapy
Obsessive-compulsive disorders
OCD
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Rest - physiology
Resting state
rTMS
tDCS
Transcranial Magnetic Stimulation - methods
Treatment Outcome
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Summary:The effect of transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) on psychopathological symptoms and resting state brain activity was assessed in a patient with obsessive-compulsive disorder (OCD). tDCS and rTMS had no effect on OC symptoms. tDCS, however, improved depression and anxiety. Functional magnetic resonance imaging at baseline showed an interhemispheric asymmetry with hyperactivation of the left and hypoactivation of the right anterior neural circuits. A reduction of interhemispheric imbalance was detected after tDCS but not after rTMS. tDCS seems to be more effective than rTMS in restoring interhemispheric imbalance and improving anxiety and depression in OCD.
ISSN:1355-4794
1465-3656
DOI:10.1080/13554794.2012.667131