effects of high-intensity exercise on neural responses to images of food

• Published in: The American journal of clinical nutrition 2014-02, Vol.99 (2), p.258-267
• Main Authors: Crabtree, Daniel R, Chambers, Edward S, Hardwick, Robert M, Blannin, Andrew K
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Appetite; Appetite - physiology; Appetite Regulation - physiology; Body Mass Index; body water; Choice Behavior - physiology; clinical nutrition; correlated responses; cortex; Cross-Over Studies; Energy Intake; Exercise; Exercise - physiology; Female; Food; Food Preferences - psychology; ghrelin; hippocampus; Hormones; Humans; hunger; image analysis; Image Processing, Computer-Assisted; low calorie foods; Magnetic Resonance Imaging; Male; men; Neurosciences; NMR; Nuclear magnetic resonance; peptide YY; Photic Stimulation; Prefrontal Cortex - physiology; Reward; temperature; thirst; Young Adult
• ISSN: 0002-9165; 1938-3207
• DOI: 10.3945/ajcn.113.071381

Background: Acute bouts of high-intensity exercise modulate peripheral appetite regulating hormones to transiently suppress hunger. However, the effects of physical activity on central appetite regulation have yet to be fully investigated.Objective: We used functional magnetic resonance imaging (fMRI) to compare neural responses to visual food stimuli after intense exercise and rest.Design: Fifteen lean healthy men [mean ± SD age: 22.5 ± 3.1 y; mean ± SD body mass index (in kg/m2): 24.2 ± 2.4] completed two 60-min trials—exercise (EX; running at ∼70% maximum aerobic capacity) and a resting control trial (REST)—in a counterbalanced order. After each trial, an fMRI assessment was completed in which images of high- and low-calorie foods were viewed.Results: EX significantly suppressed subjective appetite responses while increasing thirst and core-body temperature. Furthermore, EX significantly suppressed ghrelin concentrations and significantly enhanced peptide YY release. Neural responses to images of high-calorie foods significantly increased dorsolateral prefrontal cortex activation and suppressed orbitofrontal cortex (OFC) and hippocampus activation after EX compared with REST. After EX, low-calorie food images increased insula and putamen activation and reduced OFC activation compared with REST. Furthermore, left pallidum activity was significantly elevated after EX when low-calorie images were viewed and was suppressed when high-calorie images were viewed, and these responses correlated significantly with thirst.Conclusions: Exercise increases neural responses in reward-related regions of the brain in response to images of low-calorie foods and suppresses activation during the viewing of high-calorie foods. These central responses are associated with exercise-induced changes in peripheral signals related to appetite-regulation and hydration status. This trial was registered at www.clinicaltrials.gov as NCT01926431.