Unilateral imagined movement increases interhemispheric inhibition from the contralateral to ipsilateral motor cortex

Whether a cortical drive to one limb modulates interhemispheric inhibition (IHI) from the active targeting to the non-active motor cortex (M1) remained unclear. The present study using a conditioning-test transcranial magnetic stimulation (TMS) paradigm aimed to directly demonstrate the modulation o...

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Bibliographic Details
Published in:Experimental brain research 2014-06, Vol.232 (6), p.1823-1832
Main Authors: Liang, Nan, Funase, Kozo, Takahashi, Makoto, Matsukawa, Kanji, Kasai, Tatsuya
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Evoked potentials (Electrophysiology)
Evoked Potentials, Motor - physiology
Feedback, Sensory - physiology
Female
Functional Laterality - physiology
Fundamental and applied biological sciences. Psychology
Health sciences
Humans
Imagination - physiology
Magnetic brain stimulation
Male
Motor cortex
Motor Cortex - physiology
Movement - physiology
Muscle Contraction - physiology
Muscle, Skeletal - innervation
Neural Inhibition - physiology
Neurology
Neurosciences
Physiological aspects
Research Article
Transcranial Magnetic Stimulation
Vertebrates: nervous system and sense organs
Young Adult
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Summary:Whether a cortical drive to one limb modulates interhemispheric inhibition (IHI) from the active targeting to the non-active motor cortex (M1) remained unclear. The present study using a conditioning-test transcranial magnetic stimulation (TMS) paradigm aimed to directly demonstrate the modulation of IHI during unilateral voluntary or imagined movement in humans. Subjects were asked to actually perform right index-finger abduction (10–70 % of the maximum voluntary contraction) or to imagine the movement. Conditioning and test TMS with an interstimulus interval of 5, 10, and 15 ms were applied over the left and right M1, respectively, and the test motor evoked potential (MEP) was recorded from the left first dorsal interosseous (FDI) muscle. The conditioning TMS intensity was adjusted ranging from 0.6 to 1.4 (in 0.2 steps) times the resting motor threshold (rMT). With test TMS alone, MEP in the left FDI muscle significantly increased during voluntary or imagined movement of the right index-finger. MEP amplitude was significantly reduced in proportion to increments of the conditioning TMS intensity at rest (1.2 and 1.4 times the rMT, P  
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-014-3874-4