Modulation of the N30 generators of the somatosensory evoked potentials by the mirror neuron system

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2014-07, Vol.95, p.48-60
• Main Authors: Cebolla, A.M., Palmero-Soler, E., Dan, B., Cheron, G.
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Brain - physiology; Brain Mapping; Brain research; Electroencephalography; Evoked Potentials, Somatosensory - physiology; Female; Fundamental and applied biological sciences. Psychology; Generators; Humans; Male; Medical research; Mirror Neurons - physiology; Signal Processing, Computer-Assisted; Vertebrates: nervous system and sense organs
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2014.03.039

The N30 component of the somatosensory evoked potential is known to be modulated by sensory interference, motor action, movement ideation and observation. We introduce a new paradigm in which the observation task of another person's hand movement triggers the somatosensory stimulus, inducing the N30 response in participants. In order to identify the possible contribution of the mirror neuron network (MNN) to this early sensorimotor processing, we analyzed the N30 topography, the event-related spectral perturbation and the inter-trial coherence on single electroencephalogram (EEG) trials, and we applied swLORETA to localize the N30 sources implicated in the time–frequency domain at rest and during observation, as well as the generators differentiating these two contextual brain states. We found that N30 amplitude increase correlated with increased contralateral precentral alpha, frontal beta, and contralateral frontal gamma power spectrum, and with central and precentral alpha and parietal beta phase-locking of ongoing EEG signals. We demonstrate specific activation of the contralateral post-central and parietal cortex where the angular gyrus (BA39), an important MNN node, is implicated in this enhancement during observation. We conclude that this part of the MNN, involved in proprioceptive processing and more complex body-action representations, is already active prior to somatosensory input and may enhance N30. •We studied time–frequency sources of N30 SEP component during movement observation.•Movement observation was temporally adjusted to somatosensory stimuli.•Mirror neuron system is involved on increased N30 during observation.•N30 SEP component is an index of sensorimotor processing.•N30 SEP also integrates contribution from the mirror neuron system.