Circadian rhythms in leukocyte trafficking

A broad range of immunological processes oscillates over the course of a day. Recent findings have identified a molecular basis for the circadian clock in the regulation of the immune system. These rhythms manifest themselves in oscillatory behavior of immune cells and proinflammatory mediators, whi...

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Bibliographic Details
Published in:Seminars in immunopathology 2014-03, Vol.36 (2), p.149-162
Main Authors: Druzd, David, de Juan, Alba, Scheiermann, Christoph
Format: Article
Language:English
Subjects:
Animals
ARNTL Transcription Factors - genetics
ARNTL Transcription Factors - metabolism
Biomedical and Life Sciences
Biomedicine
Cell Movement
Circadian Clocks - physiology
Circadian rhythm
Circadian Rhythm - physiology
CLOCK Proteins - genetics
CLOCK Proteins - metabolism
Feedback
Hematopoietic Stem Cells
Homeostasis
Humans
Hydrocarbons
Immune system
Immune System Diseases - genetics
Immune System Diseases - immunology
Immune System Diseases - metabolism
Immunology
Internal Medicine
Leukocytes
Leukocytes - physiology
Organisms
Phenotype
Physiology
Proteins
Review
Stem Cell Niche
Transcription factors
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Summary:A broad range of immunological processes oscillates over the course of a day. Recent findings have identified a molecular basis for the circadian clock in the regulation of the immune system. These rhythms manifest themselves in oscillatory behavior of immune cells and proinflammatory mediators, which causes a time-dependent sensitivity in the reaction to pathogens. This rhythmicity impacts disease manifestations and severity and provides an option for therapy that incorporates chronopharmacological considerations. This review will focus on the current knowledge and relevance of rhythmic immune cell trafficking. It will provide an overview of the molecular clock machinery and its interrelations with leukocyte migration and the immune response.
ISSN:1863-2297
0344-4325
1863-2300
DOI:10.1007/s00281-013-0414-4