Arginine-vasopressin receptor gene (AVPR1A, AVPR1B) polymorphisms and their relation to personality traits

The present study aimed to assess the main effects of AVPR1A (rs11174811, RS1) and AVPR1B (rs28632197, rs33911258) gene polymorphisms, as well as haplotypic, GxE and GxG effects on personality trait variation in 1018 healthy individuals, considering gender and ethnicity confounding. Haplotype analys...

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Bibliographic Details
Published in:Russian journal of genetics 2014-03, Vol.50 (3), p.298-307
Main Authors: Kazantseva, A. V, Kutlumbetova, Yu. Yu, Malykh, S. B, Lobaskova, M. M, Khusnutdinova, E. K
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
arginine vasopressin
Biomedical and Life Sciences
Biomedicine
environmental factors
gender
genes
genetic markers
genetic polymorphism
haplotypes
Human Genetics
Microbial Genetics and Genomics
nationalities and ethnic groups
parturition
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Summary:The present study aimed to assess the main effects of AVPR1A (rs11174811, RS1) and AVPR1B (rs28632197, rs33911258) gene polymorphisms, as well as haplotypic, GxE and GxG effects on personality trait variation in 1018 healthy individuals, considering gender and ethnicity confounding. Haplotype analysis revealed an association of AVPR1A C*S- and C*L-haplotype (rs11174811 and RS1, respectively) and increased (P FDR = 0.016) or decreased (P FDR = 0.031) Extraversion (EPI) in Bashkirs, respectively. The association of AVPR1B G*A-haplotype (rs28632197 and rs33911258, respectively) and decreased Self-transcendence (TCI-125) (P FDR = 0.040) was demonstrated in the total sample and in Udmurts. GxE analysis revealed that the birth season modulated the involvement of the AVPR1A (rs11174811) gene marker in the variation of Persistence (TCI-125) in the total sample (P FDR = 0.012). The modulating effect of several environmental factors (ethnicity and birth season) on the association of AVPR1A and AVPR1B gene polymorphisms and personality traits was established.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795414030041