Clinical efficacy and compliance of sublingual immunotherapy with Dermatophagoides farinae drops in patients with atopic dermatitis

Background The oral route for administration of allergen immunotherapy has been explored since the 1900s. We attempted to evaluate the efficacy and safety of sublingual immunotherapy (SLIT) with Dermatophagoides farinae drops in patients with atopic dermatitis (AD) and investigate related factors in...

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Bibliographic Details
Published in:International journal of dermatology 2014-05, Vol.53 (5), p.650-655
Main Authors: Qin, Yu-E, Mao, Jing-Ran, Sang, Yue-chan, Li, Wen-Xiu
Format: Article
Language:English
Subjects:
Adult
Animals
Dermatitis, Atopic - therapy
Dermatophagoides farinae
Female
Humans
Male
Patient Compliance
Sublingual Immunotherapy
Treatment Outcome
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Summary:Background The oral route for administration of allergen immunotherapy has been explored since the 1900s. We attempted to evaluate the efficacy and safety of sublingual immunotherapy (SLIT) with Dermatophagoides farinae drops in patients with atopic dermatitis (AD) and investigate related factors influencing the patients' compliance. Methods A total of 107 patients with AD were randomized to receive either D. farinae drops plus pharmacotherapy (treatment group, n = 58) or only pharmacotherapy (control group, n = 49). Patients' compliance, the total effective rate, daily drug scores, visual analogue scale (VAS) scores, and IgG4 level were compared respectively between two groups at different time points. Results Twenty‐three cases have withdrawn from the study. The total effective rate in the treatment group (77.78%) was significantly higher than the control group (53.85%) (P 
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.12302