Depo-Provera effects on Wistar rat performance in the Y-maze

Medroxyprogesterone acetate is the most commonly used progestin component of hormone therapy. The goal of the present study was to determine whether Medroxyprogesterone affects rat behavior using a Y-maze test. Twenty-four Female Wistar rats were randomly selected into three groups; control group, a...

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Bibliographic Details
Published in:Metabolic brain disease 2014-06, Vol.29 (2), p.529-531
Main Authors: Okojie, A. K., Oyekunle, O. A.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Female
Maze Learning - drug effects
Maze Learning - physiology
Medroxyprogesterone Acetate - pharmacology
Metabolic Diseases
Neurology
Neurosciences
Oncology
Original Paper
Psychomotor Performance - drug effects
Psychomotor Performance - physiology
Rats
Rats, Wistar
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Summary:Medroxyprogesterone acetate is the most commonly used progestin component of hormone therapy. The goal of the present study was to determine whether Medroxyprogesterone affects rat behavior using a Y-maze test. Twenty-four Female Wistar rats were randomly selected into three groups; control group, a low dose (13 mg/ml MPA) group and a high dose (33 mg/1 ml MPA) group. Doses of Medroxyprogesterone were delivered by intramuscular injection for a period of 3 weeks. Medroxyprogesterone administration resulted in a decrease in memory and locomotion activity of rats ( p  
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-013-9460-9