Cortical thickness at the time of the initial attack in two patients with paediatric relapsing–remitting multiple sclerosis

Abstract Background Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system with a low incidence in the paediatric population; cortical atrophy is often striking, even in the early stages of the disease. Evidence of cortical thinning in childhood MS is scant. Aims Th...

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Bibliographic Details
Published in:European journal of paediatric neurology 2014-05, Vol.18 (3), p.295-300
Main Authors: Fernández-Jaén, Alberto, Fernández-Mayoralas, Daniel Martín, Fernández-Perrone, Ana Laura, Jiménez de la Peña, Mar, Recio Rodríguez, Manuel, Calleja-Pérez, Beatriz, Muñoz Jareño, Nuria, Arroyo, Rafael, Albert, Jacobo
Format: Article
Language:English
Subjects:
Adolescent
Atrophy
Cerebral Cortex - pathology
Child
Cortical
Disease Progression
Female
Gray matter
Gray Matter - pathology
Humans
Magnetic Resonance Imaging
Male
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - diagnosis
Multiple Sclerosis, Relapsing-Remitting - pathology
Neurology
Paediatric
Pediatrics
Time
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Summary:Abstract Background Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system with a low incidence in the paediatric population; cortical atrophy is often striking, even in the early stages of the disease. Evidence of cortical thinning in childhood MS is scant. Aims This study aimed to assess cortical thickness in paediatric patients during the initial attack of remitting–relapsing MS. Methods We report two cases of remitting–relapsing MS, with initial attacks at 12 and 16 years of age. We analysed brain cortical thickness (CTh) in these patients and compared these data to the CTh of a control group comprised of six 12-year-old females and six 16-year-old males. Results Both cases exhibited a total brain CTh significantly below that of the control group. This difference was also observed when analysing the CTh of all lobes except the left parietal lobe in one of the cases. Conclusions Cortical atrophy is already present at the time of onset of MS. Studies with larger patient populations that have a more homogenous clinical presentation could identify the time of onset of cortical atrophy and use this parameter as a prognostic and/or treatment marker of MS.
ISSN:1090-3798
1532-2130
DOI:10.1016/j.ejpn.2013.12.002