Profiling the approach to the investigation of viral infections in cases of sudden unexpected death in infancy in the Western Cape Province, South Africa

Highlights • Routine viral culture is done on lung tissue of infants after unexplained death. • Retrospective data showed extremely low viral culture positive yield. • We investigated two additional diagnostic methods to test for the same viruses. • We propose re-evaluation of the viral test panel a...

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Bibliographic Details
Published in:Forensic science international 2014-06, Vol.239, p.27-30
Main Authors: Burger, Marilize C, Dempers, Johan J, de Beer, Corena
Format: Article
Language:English
Subjects:
Adenoviridae - genetics
Adenoviridae - isolation & purification
Adenovirus
Age
Agreements
Cytomegalovirus
Cytomegalovirus - genetics
Cytomegalovirus - isolation & purification
Diagnosis
Female
Forensic Pathology
Forensic sciences
Humans
Immunohistochemistry
Infant
Infections
Lung - pathology
Lung - virology
Male
Medical Audit
Medical research
Mortality
Pathology
Polymerase chain reaction
Real-time PCR
Real-Time Polymerase Chain Reaction
Respiratory syncytial virus
Respiratory Syncytial Viruses - genetics
Respiratory Syncytial Viruses - isolation & purification
Retrospective Studies
Shell vial cultures
South Africa - epidemiology
Sudden Infant Death - epidemiology
SUDI/SIDS
Sudis
Viral infection
Viral infections
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Summary:Highlights • Routine viral culture is done on lung tissue of infants after unexplained death. • Retrospective data showed extremely low viral culture positive yield. • We investigated two additional diagnostic methods to test for the same viruses. • We propose re-evaluation of the viral test panel and diagnostic methods to be used.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2014.03.007