In-vitro activity of FCE 22101 against respiratory tract pathogens with reference to production of beta -lactamases

FCE 22101 is a new penem with broad antibacterial spectrum, excluding the pseudomonads, and has stability to many beta -lactamases. FCE 22101 and imipenem were very potent against the bacteria studied, including beta -lactamase producing strains, which can be isolated from patients with respiratory...

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Bibliographic Details
Main Authors: Dornbusch, K, Kronval, G, Goeransson, E, Moertsell, E
Format: Conference Proceeding
Language:English
Online Access:Get full text
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Summary:FCE 22101 is a new penem with broad antibacterial spectrum, excluding the pseudomonads, and has stability to many beta -lactamases. FCE 22101 and imipenem were very potent against the bacteria studied, including beta -lactamase producing strains, which can be isolated from patients with respiratory tract infections (MIC less than or equal to 8 mg/l). No strains were found to be resistant to FCE 22101. FCE 22101 was rapidly bactericidal and more stable to inactivation by beta -lactamases from Branhamella catarrhalis, Haemophilus influenzae, Enterobacter cloacae and Klebsiella pneumoniae than imipenem and ceftibuten. The other antibiotics tested varied in their activities against the respiratory tract pathogens.
ISSN:0305-7453