Distribution of Graphene Oxide and TiO₂-Graphene Oxide Composite in A549 Cells

Graphene and its derivatives are increasingly applied in nanoelectronics, biosensing, drug delivery, and biomedical applications. However, the information about its cytotoxicity remains limited. Herein, the distribution and cytotoxicity of graphene oxide (GO) and TiO₂-graphene oxide composite (TiO₂-...

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Bibliographic Details
Published in:Biological trace element research 2014-06, Vol.159 (1-3), p.393-398
Main Authors: Jin, Chan, Wang, Fude, Tang, Ying, Zhang, Xiangzhi, Wang, Jianqiang, Yang, Yongji
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cell Line, Tumor
Cell Survival - drug effects
cell viability
Composite materials
cytoplasm
Cytotoxicity
Drug delivery systems
drugs
graphene
Graphite - chemistry
Humans
Life Sciences
nanoparticles
Nanoparticles - adverse effects
Nanoparticles - chemistry
Nanoparticles - metabolism
Nutrition
Oncology
Oxidative stress
Oxidative Stress - drug effects
Reactive Oxygen Species
Titanium - chemistry
Titanium dioxide
Trace elements
ultrastructure
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Summary:Graphene and its derivatives are increasingly applied in nanoelectronics, biosensing, drug delivery, and biomedical applications. However, the information about its cytotoxicity remains limited. Herein, the distribution and cytotoxicity of graphene oxide (GO) and TiO₂-graphene oxide composite (TiO₂-GO composite) were evaluated in A549 cells. Cell viability and cell ultrastructure were measured. Our results indicated that GO could enter A549 cells and located in the cytoplasm and nucleus without causing any cell damage. TiO₂ nanoparticles and GO would be separated after TiO₂-GO composite entered A549 cells. TiO₂-GO composite could induce cytotoxicity similar to TiO₂ nanoparticles, which was probably attributed to oxidative stress. These results should be considered in the development of biological applications of GO and TiO₂-GO composite.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-014-0027-3