Antibiotics from myxobacteria

Covering: up to the end of 2013. Myxobacteria produce a vast range of structurally diverse natural products with prominent biological activities. Here, we provide a detailed description and judge the potential of all antibiotically active myxobacterial compounds as lead structures, pointing out thei...

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Bibliographic Details
Published in:Natural product reports 2014-01, Vol.31 (7), p.953-972
Main Authors: Schäberle, Till F, Lohr, Friederike, Schmitz, Alexander, König, Gabriele M
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Humans
Mice
Molecular Structure
Myxococcales - chemistry
Myxococcales - metabolism
Rats
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Summary:Covering: up to the end of 2013. Myxobacteria produce a vast range of structurally diverse natural products with prominent biological activities. Here, we provide a detailed description and judge the potential of all antibiotically active myxobacterial compounds as lead structures, pointing out their particularities and, if known, their mode of action. Thus, the review provides an overview of the potential of specific compounds, suitable for future investigations and possible clinical applications.
ISSN:0265-0568
1460-4752
DOI:10.1039/c4np00011k