Loading…

Indocyanine green dye angiography accurately predicts survival in the zone of ischemia in a burn comb model

Abstract Introduction Surgical evaluation of burn depth is performed via clinical observation, with only moderate reliability. While perfusion analysis has been proposed to enhance accuracy, no perfusion study has attempted to predict burn extension into the area of ischemia surrounding the original...

Full description

Saved in:
Bibliographic Details
Published in:Burns 2014-08, Vol.40 (5), p.940-946
Main Authors: Fourman, Mitchell S, Phillips, Brett T, Crawford, Laurie, McClain, Steve A, Lin, Fubao, Thode, Henry C, Dagum, Alexander B, Singer, Adam J, Clark, Richard A
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c414t-574e6962d6d749cc6eccb27e28f2ed290dac65d75e5e3539f0e44b270b0a2bd33
cites cdi_FETCH-LOGICAL-c414t-574e6962d6d749cc6eccb27e28f2ed290dac65d75e5e3539f0e44b270b0a2bd33
container_end_page 946
container_issue 5
container_start_page 940
container_title Burns
container_volume 40
creator Fourman, Mitchell S
Phillips, Brett T
Crawford, Laurie
McClain, Steve A
Lin, Fubao
Thode, Henry C
Dagum, Alexander B
Singer, Adam J
Clark, Richard A
description Abstract Introduction Surgical evaluation of burn depth is performed via clinical observation, with only moderate reliability. While perfusion analysis has been proposed to enhance accuracy, no perfusion study has attempted to predict burn extension into the area of ischemia surrounding the original insult. We examined whether laser Doppler imaging (LDI) and indocyanine green (ICG) angiography predicted survival in the zone of ischemia in a porcine hot comb burn model. Methodology Six full-thickness wounds were created on 5 female Yorkshire swine using a validated porcine hot comb burn model. 4 full-thickness burns were created separated by 3 unburned interspaces that represent the zone of ischemia. The interspaces between each comb burn were monitored using LDI and ICG Angiography at 1, 4, 24, and 48 h after burn. Interspace survival was assessed via gross observation and blinded histological readings 7 days after injury. Results ICG Angiographic assessments of burn perfusion were significantly different in viable vs. non-viable interspace perfusion at 1 h, 4 h, and 48 h. Temporal plotting of a trend-line derived from quantitative perfusion measurements rendered two distinct graphs, allowing for the derivation of a predictive algorithm to separate viable and non-viable interspaces. LDI revealed no such prognostic trend. Conclusion Results from a validated porcine burn comb model suggest that ICG angiography has significant potential in the prediction of burn progression early after burn. However, the full potential of this technology cannot be determined until completion of clinical trials.
doi_str_mv 10.1016/j.burns.2013.10.017
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1535622383</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0305417913003471</els_id><sourcerecordid>1535622383</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-574e6962d6d749cc6eccb27e28f2ed290dac65d75e5e3539f0e44b270b0a2bd33</originalsourceid><addsrcrecordid>eNqFkU2P0zAQhi0EYsvCL0BCPnJJ8WfSHEBCKz5WWokDcLac8aR1N7GLnVQKvx6HLhy4MBdLr953ZvwMIS8523LG6zfHbTenkLeCcVmULePNI7Lhu6atuGLtY7JhkulK8aa9Is9yPrJSeseekiuhhOSqVhtyfxtchMUGH5DuE2KgbkFqw97HfbKnw0ItwJzshMNCTwmdhynTPKezP9uB-kCnA9KfscRjT32GA47errql634U4tjRMTocnpMnvR0yvnh4r8n3jx--3Xyu7r58ur15f1eB4mqqdKOwbmvhateoFqBGgE40KHa9QCda5izU2jUaNUot256hUsXAOmZF56S8Jq8vfU8p_pgxT2Yse-Ew2IBxzoZrqWsh5G61yosVUsw5YW9OyY82LYYzs1I2R_Obslkpr2KhXFKvHgbM3Yjub-YP1mJ4ezFg-ebZYzIZPAYo9BLCZFz0_xnw7p88DD54sMM9LpiPsSQKQcNNFoaZr-uh1ztzyZhUDZe_AIXspSk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1535622383</pqid></control><display><type>article</type><title>Indocyanine green dye angiography accurately predicts survival in the zone of ischemia in a burn comb model</title><source>ScienceDirect Journals</source><creator>Fourman, Mitchell S ; Phillips, Brett T ; Crawford, Laurie ; McClain, Steve A ; Lin, Fubao ; Thode, Henry C ; Dagum, Alexander B ; Singer, Adam J ; Clark, Richard A</creator><creatorcontrib>Fourman, Mitchell S ; Phillips, Brett T ; Crawford, Laurie ; McClain, Steve A ; Lin, Fubao ; Thode, Henry C ; Dagum, Alexander B ; Singer, Adam J ; Clark, Richard A</creatorcontrib><description>Abstract Introduction Surgical evaluation of burn depth is performed via clinical observation, with only moderate reliability. While perfusion analysis has been proposed to enhance accuracy, no perfusion study has attempted to predict burn extension into the area of ischemia surrounding the original insult. We examined whether laser Doppler imaging (LDI) and indocyanine green (ICG) angiography predicted survival in the zone of ischemia in a porcine hot comb burn model. Methodology Six full-thickness wounds were created on 5 female Yorkshire swine using a validated porcine hot comb burn model. 4 full-thickness burns were created separated by 3 unburned interspaces that represent the zone of ischemia. The interspaces between each comb burn were monitored using LDI and ICG Angiography at 1, 4, 24, and 48 h after burn. Interspace survival was assessed via gross observation and blinded histological readings 7 days after injury. Results ICG Angiographic assessments of burn perfusion were significantly different in viable vs. non-viable interspace perfusion at 1 h, 4 h, and 48 h. Temporal plotting of a trend-line derived from quantitative perfusion measurements rendered two distinct graphs, allowing for the derivation of a predictive algorithm to separate viable and non-viable interspaces. LDI revealed no such prognostic trend. Conclusion Results from a validated porcine burn comb model suggest that ICG angiography has significant potential in the prediction of burn progression early after burn. However, the full potential of this technology cannot be determined until completion of clinical trials.</description><identifier>ISSN: 0305-4179</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/j.burns.2013.10.017</identifier><identifier>PMID: 24231464</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Angiography ; Animals ; Burn conversion ; Burns - diagnosis ; Coloring Agents ; Critical Care ; Disease Models, Animal ; Female ; Fluorescence ; Indocyanine Green ; Ischemia - diagnosis ; Laser-Doppler Flowmetry ; Near infrared ; Perfusion Imaging - methods ; Prediction ; Skin - blood supply ; Skin - diagnostic imaging ; Skin - injuries ; Swine ; Tissue Survival</subject><ispartof>Burns, 2014-08, Vol.40 (5), p.940-946</ispartof><rights>Elsevier Ltd and ISBI</rights><rights>2013 Elsevier Ltd and ISBI</rights><rights>Copyright © 2013 Elsevier Ltd and ISBI. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-574e6962d6d749cc6eccb27e28f2ed290dac65d75e5e3539f0e44b270b0a2bd33</citedby><cites>FETCH-LOGICAL-c414t-574e6962d6d749cc6eccb27e28f2ed290dac65d75e5e3539f0e44b270b0a2bd33</cites><orcidid>0000-0002-3684-4585</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24231464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fourman, Mitchell S</creatorcontrib><creatorcontrib>Phillips, Brett T</creatorcontrib><creatorcontrib>Crawford, Laurie</creatorcontrib><creatorcontrib>McClain, Steve A</creatorcontrib><creatorcontrib>Lin, Fubao</creatorcontrib><creatorcontrib>Thode, Henry C</creatorcontrib><creatorcontrib>Dagum, Alexander B</creatorcontrib><creatorcontrib>Singer, Adam J</creatorcontrib><creatorcontrib>Clark, Richard A</creatorcontrib><title>Indocyanine green dye angiography accurately predicts survival in the zone of ischemia in a burn comb model</title><title>Burns</title><addtitle>Burns</addtitle><description>Abstract Introduction Surgical evaluation of burn depth is performed via clinical observation, with only moderate reliability. While perfusion analysis has been proposed to enhance accuracy, no perfusion study has attempted to predict burn extension into the area of ischemia surrounding the original insult. We examined whether laser Doppler imaging (LDI) and indocyanine green (ICG) angiography predicted survival in the zone of ischemia in a porcine hot comb burn model. Methodology Six full-thickness wounds were created on 5 female Yorkshire swine using a validated porcine hot comb burn model. 4 full-thickness burns were created separated by 3 unburned interspaces that represent the zone of ischemia. The interspaces between each comb burn were monitored using LDI and ICG Angiography at 1, 4, 24, and 48 h after burn. Interspace survival was assessed via gross observation and blinded histological readings 7 days after injury. Results ICG Angiographic assessments of burn perfusion were significantly different in viable vs. non-viable interspace perfusion at 1 h, 4 h, and 48 h. Temporal plotting of a trend-line derived from quantitative perfusion measurements rendered two distinct graphs, allowing for the derivation of a predictive algorithm to separate viable and non-viable interspaces. LDI revealed no such prognostic trend. Conclusion Results from a validated porcine burn comb model suggest that ICG angiography has significant potential in the prediction of burn progression early after burn. However, the full potential of this technology cannot be determined until completion of clinical trials.</description><subject>Angiography</subject><subject>Animals</subject><subject>Burn conversion</subject><subject>Burns - diagnosis</subject><subject>Coloring Agents</subject><subject>Critical Care</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Indocyanine Green</subject><subject>Ischemia - diagnosis</subject><subject>Laser-Doppler Flowmetry</subject><subject>Near infrared</subject><subject>Perfusion Imaging - methods</subject><subject>Prediction</subject><subject>Skin - blood supply</subject><subject>Skin - diagnostic imaging</subject><subject>Skin - injuries</subject><subject>Swine</subject><subject>Tissue Survival</subject><issn>0305-4179</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkU2P0zAQhi0EYsvCL0BCPnJJ8WfSHEBCKz5WWokDcLac8aR1N7GLnVQKvx6HLhy4MBdLr953ZvwMIS8523LG6zfHbTenkLeCcVmULePNI7Lhu6atuGLtY7JhkulK8aa9Is9yPrJSeseekiuhhOSqVhtyfxtchMUGH5DuE2KgbkFqw97HfbKnw0ItwJzshMNCTwmdhynTPKezP9uB-kCnA9KfscRjT32GA47errql634U4tjRMTocnpMnvR0yvnh4r8n3jx--3Xyu7r58ur15f1eB4mqqdKOwbmvhateoFqBGgE40KHa9QCda5izU2jUaNUot256hUsXAOmZF56S8Jq8vfU8p_pgxT2Yse-Ew2IBxzoZrqWsh5G61yosVUsw5YW9OyY82LYYzs1I2R_Obslkpr2KhXFKvHgbM3Yjub-YP1mJ4ezFg-ebZYzIZPAYo9BLCZFz0_xnw7p88DD54sMM9LpiPsSQKQcNNFoaZr-uh1ztzyZhUDZe_AIXspSk</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Fourman, Mitchell S</creator><creator>Phillips, Brett T</creator><creator>Crawford, Laurie</creator><creator>McClain, Steve A</creator><creator>Lin, Fubao</creator><creator>Thode, Henry C</creator><creator>Dagum, Alexander B</creator><creator>Singer, Adam J</creator><creator>Clark, Richard A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3684-4585</orcidid></search><sort><creationdate>20140801</creationdate><title>Indocyanine green dye angiography accurately predicts survival in the zone of ischemia in a burn comb model</title><author>Fourman, Mitchell S ; Phillips, Brett T ; Crawford, Laurie ; McClain, Steve A ; Lin, Fubao ; Thode, Henry C ; Dagum, Alexander B ; Singer, Adam J ; Clark, Richard A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-574e6962d6d749cc6eccb27e28f2ed290dac65d75e5e3539f0e44b270b0a2bd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Angiography</topic><topic>Animals</topic><topic>Burn conversion</topic><topic>Burns - diagnosis</topic><topic>Coloring Agents</topic><topic>Critical Care</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Indocyanine Green</topic><topic>Ischemia - diagnosis</topic><topic>Laser-Doppler Flowmetry</topic><topic>Near infrared</topic><topic>Perfusion Imaging - methods</topic><topic>Prediction</topic><topic>Skin - blood supply</topic><topic>Skin - diagnostic imaging</topic><topic>Skin - injuries</topic><topic>Swine</topic><topic>Tissue Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fourman, Mitchell S</creatorcontrib><creatorcontrib>Phillips, Brett T</creatorcontrib><creatorcontrib>Crawford, Laurie</creatorcontrib><creatorcontrib>McClain, Steve A</creatorcontrib><creatorcontrib>Lin, Fubao</creatorcontrib><creatorcontrib>Thode, Henry C</creatorcontrib><creatorcontrib>Dagum, Alexander B</creatorcontrib><creatorcontrib>Singer, Adam J</creatorcontrib><creatorcontrib>Clark, Richard A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fourman, Mitchell S</au><au>Phillips, Brett T</au><au>Crawford, Laurie</au><au>McClain, Steve A</au><au>Lin, Fubao</au><au>Thode, Henry C</au><au>Dagum, Alexander B</au><au>Singer, Adam J</au><au>Clark, Richard A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indocyanine green dye angiography accurately predicts survival in the zone of ischemia in a burn comb model</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>40</volume><issue>5</issue><spage>940</spage><epage>946</epage><pages>940-946</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><abstract>Abstract Introduction Surgical evaluation of burn depth is performed via clinical observation, with only moderate reliability. While perfusion analysis has been proposed to enhance accuracy, no perfusion study has attempted to predict burn extension into the area of ischemia surrounding the original insult. We examined whether laser Doppler imaging (LDI) and indocyanine green (ICG) angiography predicted survival in the zone of ischemia in a porcine hot comb burn model. Methodology Six full-thickness wounds were created on 5 female Yorkshire swine using a validated porcine hot comb burn model. 4 full-thickness burns were created separated by 3 unburned interspaces that represent the zone of ischemia. The interspaces between each comb burn were monitored using LDI and ICG Angiography at 1, 4, 24, and 48 h after burn. Interspace survival was assessed via gross observation and blinded histological readings 7 days after injury. Results ICG Angiographic assessments of burn perfusion were significantly different in viable vs. non-viable interspace perfusion at 1 h, 4 h, and 48 h. Temporal plotting of a trend-line derived from quantitative perfusion measurements rendered two distinct graphs, allowing for the derivation of a predictive algorithm to separate viable and non-viable interspaces. LDI revealed no such prognostic trend. Conclusion Results from a validated porcine burn comb model suggest that ICG angiography has significant potential in the prediction of burn progression early after burn. However, the full potential of this technology cannot be determined until completion of clinical trials.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>24231464</pmid><doi>10.1016/j.burns.2013.10.017</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3684-4585</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0305-4179
ispartof Burns, 2014-08, Vol.40 (5), p.940-946
issn 0305-4179
1879-1409
language eng
recordid cdi_proquest_miscellaneous_1535622383
source ScienceDirect Journals
subjects Angiography
Animals
Burn conversion
Burns - diagnosis
Coloring Agents
Critical Care
Disease Models, Animal
Female
Fluorescence
Indocyanine Green
Ischemia - diagnosis
Laser-Doppler Flowmetry
Near infrared
Perfusion Imaging - methods
Prediction
Skin - blood supply
Skin - diagnostic imaging
Skin - injuries
Swine
Tissue Survival
title Indocyanine green dye angiography accurately predicts survival in the zone of ischemia in a burn comb model
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T22%3A18%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Indocyanine%20green%20dye%20angiography%20accurately%20predicts%20survival%20in%20the%20zone%20of%20ischemia%20in%20a%20burn%20comb%20model&rft.jtitle=Burns&rft.au=Fourman,%20Mitchell%20S&rft.date=2014-08-01&rft.volume=40&rft.issue=5&rft.spage=940&rft.epage=946&rft.pages=940-946&rft.issn=0305-4179&rft.eissn=1879-1409&rft_id=info:doi/10.1016/j.burns.2013.10.017&rft_dat=%3Cproquest_cross%3E1535622383%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c414t-574e6962d6d749cc6eccb27e28f2ed290dac65d75e5e3539f0e44b270b0a2bd33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1535622383&rft_id=info:pmid/24231464&rfr_iscdi=true