Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

Covering: 2006 to 2013. Investigations on the chemistry and biology of rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species during the period 2006-2013 are reviewed. Included are new phytochemical studies of naturally occurring rocaglamide derivatives, an update o...

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Bibliographic Details
Published in:Natural product reports 2014-01, Vol.31 (7), p.924-939
Main Authors: Pan, Li, Woodard, John L, Lucas, David M, Fuchs, James R, Douglas Kinghorn, A
Format: Article
Language:English
Subjects:
Aglaia - chemistry
Animals
Benzofurans - chemistry
Benzofurans - isolation & purification
Benzofurans - pharmacology
Humans
Mice
Molecular Structure
Structure-Activity Relationship
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:Covering: 2006 to 2013. Investigations on the chemistry and biology of rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species during the period 2006-2013 are reviewed. Included are new phytochemical studies of naturally occurring rocaglamide derivatives, an update on synthetic methods for cyclopenta[ b ]benzofurans, and a description of the recent biological evaluation and mechanism-of-action studies on compounds of this type. This review summarizes recent investigations on the chemistry and biology of rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species published during the period 2006-2013.
ISSN:0265-0568
1460-4752
DOI:10.1039/c4np00006d