Desorption Mass Spectrometry for Nonvolatile Compounds Using an Ultrasonic Cutter

In this work, desorption of nonvolatile analytes induced by friction was studied. The nonvolatile compounds deposited on the perfluoroalkoxy substrate were gently touched by an ultrasonic cutter oscillating with a frequency of 40 kHz. The desorbed molecules were ionized by a dielectric barrier disch...

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Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 2014-07, Vol.25 (7), p.1177-1180
Main Authors: Habib, Ahsan, Ninomiya, Satoshi, Chen, Lee Chuin, Usmanov, Dilshadbek T., Hiraoka, Kenzo
Format: Article
Language:English
Subjects:
Amino acids
Analytical Chemistry
Bioinformatics
Biotechnology
Chemistry
Chemistry and Materials Science
Desorption
Dielectric barrier discharge
Explosives detection
Ionization
Ions
Mass spectrometry
Organic Chemistry
Proteomics
Short Communication
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Summary:In this work, desorption of nonvolatile analytes induced by friction was studied. The nonvolatile compounds deposited on the perfluoroalkoxy substrate were gently touched by an ultrasonic cutter oscillating with a frequency of 40 kHz. The desorbed molecules were ionized by a dielectric barrier discharge (DBD) ion source. Efficient desorption of samples such as drugs, pharmaceuticals, amino acids, and explosives was observed. The limits of detection for these compounds were about 1 ng. Many compounds were detected in their protonated forms without undergoing significant fragmentation. When the DBD was off, no ions for the neutral samples could be detected, meaning that only desorption along with little ionization took place by the present technique. Figure ᅟ
ISSN:1044-0305
1879-1123
DOI:10.1007/s13361-014-0899-7