Mesohepatectomy versus extended hemihepatectomy for centrally located hepatocellular carcinoma

Background Extended hemihepatectomy is usually recommended to treat large centrally located hepatocellular carcinoma (HCC). However, the morbidity and mortality are high because of the postoperative liver failure. Mesohepatectomy is seldom used because of its technical complexity. This study aimed t...

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Bibliographic Details
Published in:Hepatobiliary & pancreatic diseases international 2014-06, Vol.13 (3), p.264-270
Main Authors: Chen, Xi, Li, Bo, He, Wei, Wei, Yong-Gang, Du, Zheng-Gui, Jiang, Li
Format: Article
Language:English
Subjects:
Adult
Aged
Bilirubin - blood
Biomarkers - blood
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - secondary
Carcinoma, Hepatocellular - surgery
complication
Disease Progression
Disease-Free Survival
Endocrinology & Metabolism
extended hemihepatectomy
Female
Gastroenterology and Hepatology
Hepatectomy - adverse effects
Hepatectomy - methods
Hepatectomy - mortality
hepatocellular carcinoma
Humans
Kaplan-Meier Estimate
Liver Failure - etiology
Liver Failure - prevention & control
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
mesohepatectomy
Middle Aged
Neoplasm Recurrence, Local
Operative Time
Risk Factors
survival
Time Factors
Treatment Outcome
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Summary:Background Extended hemihepatectomy is usually recommended to treat large centrally located hepatocellular carcinoma (HCC). However, the morbidity and mortality are high because of the postoperative liver failure. Mesohepatectomy is seldom used because of its technical complexity. This study aimed to evaluate the short-term and long-term curative effect of mesohepatectomy. Methods From January 2002 to September 2008, a total of 198 consecutive patients with centrally located HCC underwent hepatectomy in our department. According to the surgical procedures, they were divided into mesohepatectomy (group M, n =118), extended right hemihepatectomy (group RE, n =47) and extended left hemihepatectomy (group LE, n =33) groups. The surgical techniques, clinical pathological characteristics and outcomes were compared between group M, group RE and group LE. Results The operative time of group M was significantly longer than that of the other two groups ( P
ISSN:1499-3872
DOI:10.1016/S1499-3872(14)60253-8