Impact of Albuminuria on the Incidence of Periprocedural Myocardial Injury in Patients Undergoing Elective Coronary Stent Implantation

Albuminuria has traditionally been associated with an elevated risk of cardiovascular events. However, few studies have examined the potential relation between albuminuria and periprocedural risk in percutaneous coronary intervention (PCI). The aim of this study was to evaluate the impact of albumin...

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Bibliographic Details
Published in:The American journal of cardiology 2014-07, Vol.114 (1), p.42-46
Main Authors: Osugi, Naohiro, MD, Suzuki, Susumu, MD, Ishii, Hideki, MD, PhD, Yasuda, Yoshinari, MD, PhD, Shibata, Yohei, MD, Tatami, Yosuke, MD, Ota, Tomoyuki, MD, Kawamura, Yoshihiro, MD, Okumura, Satoshi, MD, Tanaka, Akihito, MD, Inoue, Yosuke, MD, Matsuo, Seiichi, MD, PhD, Murohara, Toyoaki, MD, PhD
Format: Article
Language:English
Subjects:
Age
Aged
Albuminuria - complications
Angina Pectoris - therapy
Biomarkers - blood
Biomarkers - urine
Blood pressure
Cardiovascular
Cholesterol
Confidence intervals
Coronary Angiography
Creatinine - urine
Diabetes
Female
Glomerular Filtration Rate
Heart attacks
Heart Injuries - blood
Heart Injuries - etiology
Heart Injuries - urine
Humans
Hypertension
Incidence
Kidney diseases
Lipoproteins
Logistics
Male
Mortality
Myocardial Ischemia - therapy
Percutaneous Coronary Intervention
Regression analysis
Risk Factors
Stents
Troponin T - blood
Ultrasonic imaging
Variables
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Summary:Albuminuria has traditionally been associated with an elevated risk of cardiovascular events. However, few studies have examined the potential relation between albuminuria and periprocedural risk in percutaneous coronary intervention (PCI). The aim of this study was to evaluate the impact of albuminuria on the incidence of periprocedural myocardial injury (PMI) in patients who underwent PCI. The study included 252 consecutive patients who underwent PCI. The incidence of PMI was significantly higher in patients with albuminuria than in those with normoalbuminuria (31.9% vs 43.3%, respectively, p = 0.014). Even after adjustment for confounders, the presence of albuminuria predicted PMI (odds ratio 2.07, 95% confidence interval 1.08 to 3.97, p = 0.029). Furthermore, patients with albuminuria and preserved estimated glomerular filtration rate had a 4.2-fold higher risk for PMI than did patients with normoalbuminuria and preserved estimated glomerular filtration rate. In conclusion, albuminuria was a strong predictor of PMI in patients who underwent PCI.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2014.03.058