Relation of T-Wave Alternans to Mortality and Nonsustained Ventricular Tachycardia in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome from the MERLIN-TIMI 36 Trial of Ranolazine Versus Placebo

We explored the utility of T-wave alternans (TWA) in predicting mortality in patients with non–ST-segment elevation acute coronary syndrome (NSTEACS). Maximum TWA was calculated using Modified Moving Average method from continuous electrocardiographic recordings in patients with left ventricular eje...

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Bibliographic Details
Published in:The American journal of cardiology 2014-07, Vol.114 (1), p.17-23
Main Authors: Nieminen, Tuomo, MD, PhD, Scirica, Benjamin M., MD, MPH, Pegler, Jose R.M., BS, Tavares, Caio, BS, Pagotto, Vitor P.F., BS, Kanas, Alexandre F., BS, Sobrado, Marcel F., BS, Nearing, Bruce D., PhD, Umez-Eronini, Amarachi A., MS, Morrow, David A., MD, MPH, Belardinelli, Luiz, MD, Verrier, Richard L., PhD
Format: Article
Language:English
Subjects:
Acetanilides - therapeutic use
Acute Coronary Syndrome - drug therapy
Acute Coronary Syndrome - mortality
Acute Coronary Syndrome - physiopathology
Acute coronary syndromes
Aged
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - mortality
Arrhythmias, Cardiac - physiopathology
Brugada Syndrome
Cardiac arrhythmia
Cardiac Conduction System Disease
Cardiovascular
Death, Sudden, Cardiac
Electrocardiography
Enzyme Inhibitors - therapeutic use
Female
Heart attacks
Heart Conduction System - abnormalities
Heart Conduction System - physiopathology
Hospitalization
Humans
Male
Middle Aged
Mortality
Piperazines - therapeutic use
Placebos
Predictive Value of Tests
Ranolazine
Risk Factors
Tachycardia, Ventricular - drug therapy
Tachycardia, Ventricular - mortality
Tachycardia, Ventricular - physiopathology
Treatment Outcome
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Summary:We explored the utility of T-wave alternans (TWA) in predicting mortality in patients with non–ST-segment elevation acute coronary syndrome (NSTEACS). Maximum TWA was calculated using Modified Moving Average method from continuous electrocardiographic recordings in patients with left ventricular ejection fraction
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2014.03.056