Increased lung cancer risk associated with the TERT rs2736100 polymorphism: an updated meta-analysis

The rs2736100 polymorphism in the telomerase reverse transcriptase ( TERT ) gene has been implicated in lung cancer risk in multiple populations, but the existing evidence lacks statistical power to draw a convincing conclusion. Therefore, the present study was devised to derive a more precise estim...

Full description

Saved in:
Bibliographic Details
Published in:Tumor biology 2014-06, Vol.35 (6), p.5763-5769
Main Authors: Yang, Jihua, Jiao, Shunchang
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer Research
Genes
Genetic Predisposition to Disease
Humans
Lung cancer
Lung Neoplasms - etiology
Lung Neoplasms - genetics
Meta-analysis
Polymorphism
Polymorphism, Genetic
Publication Bias
Research Article
Risk
Risk factors
Telomerase
Telomerase - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The rs2736100 polymorphism in the telomerase reverse transcriptase ( TERT ) gene has been implicated in lung cancer risk in multiple populations, but the existing evidence lacks statistical power to draw a convincing conclusion. Therefore, the present study was devised to derive a more precise estimation of the association between rs2736100 and lung cancer risk. The PubMed, Embase, and Web of Science databases were comprehensively searched for papers concerning lung cancer risk in relation to rs2736100. Pooled odds ratios (ORs) and the 95 % confidence intervals (CIs) were appropriately calculated using the fixed or random effects model. Meta-analysis of 20 independent studies involving 39,715 cancer cases and 61,462 control subjects showed statistical evidence for an association between rs2736100 and increased risk of lung cancer. Subgroup analysis by ethnicity demonstrated a significant association among both Asian and Caucasian populations. We additionally found an increased risk of non-small cell lung cancer and lung adenocarcinoma strongly associated with rs2736100. These data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer.
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-014-1765-8