Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal beta-glucuronidase activity in the rat

The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of control group fed a fiber-free diet. Both kinds of...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1981-06, Vol.41 (6), p.2518-2523
Main Authors: Bauer, H G, Asp, N G, Dahlqvist, A, Fredlund, P E, Nyman, M, Oste, R
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemically induced
Animals
Bacteria - enzymology
Body Weight
Cellulose - pharmacology
Colonic Neoplasms - chemically induced
Dietary Fiber - pharmacology
Dimethylhydrazines - toxicity
Feces - analysis
Feces - enzymology
Glucuronidase - metabolism
Male
Methylhydrazines - toxicity
Pectins - pharmacology
Rats
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Summary:The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of control group fed a fiber-free diet. Both kinds of pectin increased the multiplicity of color tumors, whereas guar gum did not significantly influence carcinogenesis. Bacterial beta-glucuronidase activity in feces and colonic content was the same in pectin-fed rats and controls but significantly lower in the guar gum group. Thus, it was not related to the number of tumors in each group.
ISSN:0008-5472