Signalling pathways linking integrins with cell cycle progression

Integrins are adhesion receptors that allow cells to sense and respond to microenvironmental signals encoded by the extracellular matrix. They are crucial for the adhesion, survival, proliferation, differentiation and migration of most cell types. In cell cycle regulation, integrin-mediated signals...

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Bibliographic Details
Published in:Matrix biology 2014-02, Vol.34, p.144-153
Main Authors: Moreno-Layseca, Paulina, Streuli, Charles H.
Format: Article
Language:English
Subjects:
Adhesion complex
Akt
Cell Adhesion - genetics
Cell Cycle Checkpoints - genetics
Cell cycle progression
Cell Proliferation - genetics
ECM
Erk
Extracellular Matrix - genetics
Extracellular Matrix - metabolism
Growth factor
Humans
Integrin
Integrins - genetics
Proliferation
Rac
Signal Transduction - genetics
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Summary:Integrins are adhesion receptors that allow cells to sense and respond to microenvironmental signals encoded by the extracellular matrix. They are crucial for the adhesion, survival, proliferation, differentiation and migration of most cell types. In cell cycle regulation, integrin-mediated signals from the local niche constitute a spatial checkpoint to allow cells to progress from G1 to S phase, and are as important as temporal growth factor signals. Proliferation is altered in diseases such as cancer and fibrosis, so understanding how integrins contribute to this process will provide novel strategies for therapy. Here we consider recent studies to elucidate mechanisms of integrin-dependent cell cycle progression and discuss perspectives for future study.
ISSN:0945-053X
1569-1802
DOI:10.1016/j.matbio.2013.10.011