Negative autopsy and sudden cardiac death

Forensic medicine defines the unexplained sudden death as a death with a non-conclusive diagnosis after autopsy. Molecular diagnosis is being progressively incorporated in forensics, mainly due to improvement in genetics. New genetic technologies may help to identify the genetic cause of death, desp...

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Bibliographic Details
Published in:International journal of legal medicine 2014-07, Vol.128 (4), p.599-606
Main Authors: Campuzano, Oscar, Allegue, Catarina, Partemi, Sara, Iglesias, Anna, Oliva, Antonio, Brugada, Ramon
Format: Article
Language:English
Subjects:
Arrhythmias, Cardiac - genetics
Autopsies
Autopsy
Cardiomyopathies - genetics
Cardiovascular disease
Channelopathies - genetics
Death, Sudden, Cardiac - etiology
DNA - isolation & purification
Epilepsy
Forensic Genetics
Forensic Medicine
Genetic Testing
Genetics
Heart
Humans
Legal medicine
Medical History Taking
Medical Law
Medicine
Medicine & Public Health
Review Article
RNA, Messenger - isolation & purification
Sequence Analysis, DNA
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Summary:Forensic medicine defines the unexplained sudden death as a death with a non-conclusive diagnosis after autopsy. Molecular diagnosis is being progressively incorporated in forensics, mainly due to improvement in genetics. New genetic technologies may help to identify the genetic cause of death, despite clinical interpretation of genetic data remains the current challenge. The identification of an inheritable defect responsible for arrhythmogenic syndromes could help to adopt preventive measures in family members, many of them asymptomatic but at risk of sudden death. This multidisciplinary translational research requires a specialized team.
ISSN:0937-9827
1437-1596
DOI:10.1007/s00414-014-0966-4