Profile and treatment outcome of smear-positive TB patients who failed to smear convert after 2 months of treatment in Nigeria

Background In Nigeria, little is known about the profile and treatment outcomes of smear-positive pulmonary TB (SPPTB) patients with persistent smear positivity after 2 months of treatment. Methods A retrospective cohort study was carried out to determine the characteristics and treatment outcomes o...

Full description

Saved in:
Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2014-07, Vol.108 (7), p.431-438
Main Authors: Ukwaja, Kingsley N., Oshi, Daniel C., Oshi, Sarah N., Alobu, Isaac
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antitubercular Agents - therapeutic use
Biological and medical sciences
Cohort Studies
Female
General aspects
Humans
Male
Medical sciences
Middle Aged
Nigeria - epidemiology
Retrospective Studies
Risk Factors
Sputum - microbiology
Treatment Outcome
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - microbiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background In Nigeria, little is known about the profile and treatment outcomes of smear-positive pulmonary TB (SPPTB) patients with persistent smear positivity after 2 months of treatment. Methods A retrospective cohort study was carried out to determine the characteristics and treatment outcomes of patients with persistent smear positivity after 2 months of treatment among adults with SPPTB between 2011 and 2012 in two large health facilities in Nigeria. Findings were compared with SPPTB patients who had a negative smear conversion in the same period. Results Of 929 eligible patients, 187 (20.1%) had persistent smear positivity after 2 months of treatment. Independent predictors for persistent smear positivity were older age (p
ISSN:0035-9203
1878-3503
DOI:10.1093/trstmh/tru070