Higher body mass index in adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus is associated with lower risk HLA genes

Abstract We hypothesised that higher body weight, a proposed risk factor for type 1 diabetes mellitus, would be associated with increased penetrance of lower risk genes. In adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus we found that higher body mass index was associa...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2014-06, Vol.104 (3), p.e69-e71
Main Authors: Fourlanos, S, Elkassaby, S, Varney, M.D, Colman, P.G, Harrison, L.C
Format: Article
Language:English
Subjects:
Adult
Aged
Autoimmune Diseases - diagnosis
Autoimmune Diseases - genetics
Body Mass Index
Body weight
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - genetics
Endocrinology & Metabolism
Female
Gene penetrance
HLA
HLA-DQ Antigens - genetics
HLA-DR Antigens - genetics
Humans
LADA
Male
Middle Aged
Overweight
Risk Factors
Type 1 diabetes mellitus
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Summary:Abstract We hypothesised that higher body weight, a proposed risk factor for type 1 diabetes mellitus, would be associated with increased penetrance of lower risk genes. In adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus we found that higher body mass index was associated with the absence of the highest risk HLA genes.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2014.03.009