Non-diabetic renal disease in Croatian patients with type 2 diabetes mellitus

• Published in: Diabetes research and clinical practice 2014-06, Vol.104 (3), p.443-450
• Main Authors: Horvatic, Ivica, Tisljar, Miroslav, Kacinari, Patricia, Matesic, Ivana, Bulimbasic, Stela, Galesic Ljubanovic, Danica, Katic, Tina, Kristovic, Darko, Galesic, Kresimir
• Format: Article
• Language: English
• Subjects: Croatia - epidemiology; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Nephropathies - epidemiology; Diabetic nephropathy; Diabetic retinopathy; Endocrinology & Metabolism; Female; Glomerulonephritis, IGA - epidemiology; Glomerulonephritis, Membranous - epidemiology; Glomerulosclerosis, Focal Segmental - epidemiology; Hospitals, University; Humans; Male; Middle Aged; Non-diabetic renal disease; Prevalence; Renal biopsy; Retrospective Studies; Type 2 diabetes mellitus
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2014.03.016

Abstract Aim Our study aimed to examine the prevalence of non-diabetic renal disease in selected patients with type 2 diabetes mellitus and to determine important risk factors for non-diabetic renal disease. Methods We conducted retrospective analysis of clinical, laboratory and pathohistological data of type 2 diabetes mellitus patients in whom renal biopsies were performed from January 2004 to February 2013 at Dubrava University Hospital Zagreb Croatia ( n = 80). Results According to renal biopsy findings, isolated diabetic nephropathy was found in 46.25%, non-diabetic renal disease superimposed on diabetic nephropathy in 17.5% and isolated non-diabetic renal disease in 36.25% of the patients. The most common non-diabetic renal diseases found were: membranous nephropathy, followed by IgA nephropathy and focal segmental glomerulosclerosis. In univariate analysis shorter duration of diabetes, independence of insulin therapy, lower levels of HbA1c and absence of diabetic retinopathy were found to be significant clinical predictors of non-diabetic renal disease. In multivariate analysis only independence of insulin therapy (OR 4.418, 95%CI = 1.477–13.216) and absence of diabetic retinopathy (OR 5.579, 95%CI = 1.788–17.404) were independent predictors of non-diabetic renal disease. Conclusions This study confirmed usefulness of renal biopsy in patients with type 2 diabetes mellitus, due to the high prevalence of non-diabetic renal disease found. Since non-diabetic renal disease are potentially curable, we should consider renal biopsy in selected type 2 diabetes mellitus patients with renal involvement, especially in those with absence of diabetic retinopathy and independence of insulin therapy.