Inositol-phosphate-induced enhancement of natural killer cell activity correlates with tumor suppression

In recent studies, we have demonstrated that inositol hexaphosphate (InsP6) inhibits experimental colon carcinogenesis. Since natural killer (NK) cells are involved in tumor cell destruction, we investigated the effect of InsP6 on murine NK cell activity. We show that; (i) 1,2-dimethylhydrazine (DMH...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1989-09, Vol.10 (9), p.1595-1598
Main Authors: Baten, Abdul, Ullah, Asad, Tomazic, Vesna J., Shamsuddin, Abulkalam M.
Format: Article
Language:English
Subjects:
1,2-Dimethylhydrazine
Animals
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - pharmacology
Cells, Cultured
Cytotoxicity, Immunologic - drug effects
Dimethylhydrazines - pharmacology
General aspects
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
Male
Medical sciences
Methylhydrazines - pharmacology
Mice
Mice, Inbred C3H
Neoplasms, Experimental - pathology
Neoplasms, Experimental - prevention & control
Phytic Acid - pharmacology
Reference Values
Spleen - immunology
Tumors
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Summary:In recent studies, we have demonstrated that inositol hexaphosphate (InsP6) inhibits experimental colon carcinogenesis. Since natural killer (NK) cells are involved in tumor cell destruction, we investigated the effect of InsP6 on murine NK cell activity. We show that; (i) 1,2-dimethylhydrazine (DMH), a colon carcinogen, depresses NK activity; (ii) in vivo treatment of mice with InsP6 enhances baseline NK activity and reverses DMH-induced depressed NK activity with an inverse correlation (r = −0.9811) with tumor incidence, (iii) short-term in vitro treatment of spleen cells and NK-enriched fraction with InsP6 also enhances NK cytotoxicity in a dose-dependent manner, (iv) inositol potentiates the action of IasP6. Our data suggest yet another important role of inositol phosphates in the regulation of cellular activity.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/10.9.1595