Carboxyalkyl dipeptides with atrial natriuretic factor potentiating and antihypertensive activity

Recent reports demonstrating the ability of neutral endopeptidase (NEP) (EC 3.4.24.11) to inactivate ANF in vitro prompt the authors to report their work on NEP inhibitors that potentiate the hypotensive activity of exogenous ANF and express antihypertensive activity.

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Bibliographic Details
Published in:Journal of medicinal chemistry 1989-04, Vol.32 (4), p.737-739
Main Authors: Haslanger, Martin F, Sybertz, Edmund J, Neustadt, Bernard R, Smith, Elizabeth M, Nechuta, Terry L, Berger, Joel
Format: Article
Language:English
Subjects:
Alkylation
Animals
Atrial Natriuretic Factor - blood
Atrial Natriuretic Factor - pharmacology
Atrial Natriuretic Factor - therapeutic use
Blood Pressure - drug effects
Chemical Phenomena
Chemistry
Dipeptides - chemical synthesis
Dipeptides - pharmacology
Dipeptides - therapeutic use
Drug Synergism
Exact sciences and technology
Half-Life
Hypertension - drug therapy
Kidney - enzymology
membrane metallo-endopeptidase
Neprilysin - antagonists & inhibitors
Neprilysin - metabolism
Organic chemistry
Peptides
Preparations and properties
Rabbits
Rats
Citations: Items that cite this one
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Description
Summary:Recent reports demonstrating the ability of neutral endopeptidase (NEP) (EC 3.4.24.11) to inactivate ANF in vitro prompt the authors to report their work on NEP inhibitors that potentiate the hypotensive activity of exogenous ANF and express antihypertensive activity.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00124a002