Clozapine-induced myoclonic seizures and valproic acid

Within a 3-year period, in 220 patients receiving clozapine, we observed myoclonic seizures in two who had no previous epileptic history. Seizures appeared at the titration phase at relatively low doses, and resolved with the addition of valproic acid, allowing further increases of the clozapine dos...

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Bibliographic Details
Published in:International journal of psychiatry in clinical practice 1998, Vol.2 (1), p.53-55
Main Authors: Taner, Ender, Co ar, BehÇEt, I ik, Erdal
Format: Article
Language:English
Subjects:
clozapine
myoclonic seizures
schizophrenia
valproic acid
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Summary:Within a 3-year period, in 220 patients receiving clozapine, we observed myoclonic seizures in two who had no previous epileptic history. Seizures appeared at the titration phase at relatively low doses, and resolved with the addition of valproic acid, allowing further increases of the clozapine dose to therapeutic levels.
ISSN:1365-1501
1471-1788
DOI:10.3109/13651509809115115