Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries

Abstract Introduction Maternal nutrient restriction and decreased scotophase concentrations of melatonin have been associated with severely compromised pregnancies. We hypothesized that melatonin supplementation in a compromised pregnancy enhances the bradykinin (BK)-induced relaxations of placental...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2014-07, Vol.35 (7), p.461-466
Main Authors: Shukla, P, Lemley, C.O, Dubey, N, Meyer, A.M, O'Rourke, S.T, Vonnahme, K.A
Format: Article
Language:English
Subjects:
Angiotensin II - pharmacology
Animal Nutritional Physiological Phenomena
Animals
Arterial relaxation
Biological and medical sciences
Bradykinin - pharmacology
Diet
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Gestation
Internal Medicine
Maternal Nutritional Physiological Phenomena
Melatonin
Melatonin - administration & dosage
Melatonin - physiology
Norepinephrine - pharmacology
Nutrient restriction
Obstetrics and Gynecology
Placenta - blood supply
Placenta - drug effects
Placental blood flow
Placental Circulation - drug effects
Pregnancy
Sheep
Sheep, Domestic
Vasodilation - drug effects
Vasodilation - physiology
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Summary:Abstract Introduction Maternal nutrient restriction and decreased scotophase concentrations of melatonin have been associated with severely compromised pregnancies. We hypothesized that melatonin supplementation in a compromised pregnancy enhances the bradykinin (BK)-induced relaxations of placental arteries thereby ensuring sufficient umbilical blood flow to the developing fetus. Methods Pregnant ewes ( n  = 31) were fed an adequate (ADQ) or nutrient restricted (RES) diet supplemented with 5 mg of melatonin (MEL) or without melatonin (CON) from day 50 to 130 of gestation. On day 130 of gestation, the maternal (caruncular; CAR) and fetal (cotyledonary; COT) placental arteries were suspended in organ chambers for isometric tension recording. Results There were no treatment or dietary effects on CAR arteries for any vasoactive agent. However, in COT arteries, MEL ewes were more sensitive ( P  
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2014.04.007