Loading…
Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries
Abstract Introduction Maternal nutrient restriction and decreased scotophase concentrations of melatonin have been associated with severely compromised pregnancies. We hypothesized that melatonin supplementation in a compromised pregnancy enhances the bradykinin (BK)-induced relaxations of placental...
Saved in:
| Published in: | Placenta (Eastbourne) 2014-07, Vol.35 (7), p.461-466 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c400t-160b8b25275bbdd547ce13f4391ce4e1d11366146f018a6efa4b2f420af3227a3 |
| container_end_page | 466 |
| container_issue | 7 |
| container_start_page | 461 |
| container_title | Placenta (Eastbourne) |
| container_volume | 35 |
| creator | Shukla, P Lemley, C.O Dubey, N Meyer, A.M O'Rourke, S.T Vonnahme, K.A |
| description | Abstract Introduction Maternal nutrient restriction and decreased scotophase concentrations of melatonin have been associated with severely compromised pregnancies. We hypothesized that melatonin supplementation in a compromised pregnancy enhances the bradykinin (BK)-induced relaxations of placental arteries thereby ensuring sufficient umbilical blood flow to the developing fetus. Methods Pregnant ewes ( n = 31) were fed an adequate (ADQ) or nutrient restricted (RES) diet supplemented with 5 mg of melatonin (MEL) or without melatonin (CON) from day 50 to 130 of gestation. On day 130 of gestation, the maternal (caruncular; CAR) and fetal (cotyledonary; COT) placental arteries were suspended in organ chambers for isometric tension recording. Results There were no treatment or dietary effects on CAR arteries for any vasoactive agent. However, in COT arteries, MEL ewes were more sensitive ( P |
| doi_str_mv | 10.1016/j.placenta.2014.04.007 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1539469712</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0143400414001593</els_id><sourcerecordid>1539469712</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-160b8b25275bbdd547ce13f4391ce4e1d11366146f018a6efa4b2f420af3227a3</originalsourceid><addsrcrecordid>eNqFUl2r1DAQLaJ416t_4ZIXwZeumTRtty-iXK4fcMEH9Tmk6USypmlN0oX9N_5Up-6uoi_CkAyZM2c-ToriBvgWODQv99vZa4Mh663gILecjLcPig3UlSgr4OJhsaFAVUrO5VXxJKU957yTIB4XV0LuoKmh3hQ_7qxFk9lk2agzxqA9C0uOjqhZxESeyW4KTIeBjeh1noILLC3z7HFc6_-K2jiNbHQDyxMjDLKvlHoKkR10MovXkQg1sR1cPv5VcOW2mMm7DEVvkYIO09PikdU-4bPzfV18eXv3-fZ9ef_x3YfbN_eloQFzCQ3vd72oRVv3_TDUsjUIlZVVBwYlwgBQNQ3IxnLY6Qatlr2wUnBtKyFaXV0XL068c5y-L9S9Gl0y6L0OOC1J0V472XQtCII2J6iJU0oRrZqjG3U8KuBqVUft1WUQtaqjOBlvKfHmXGPpRxx-p13kIMDzM4A2pr2NOhiX_uB2NenXrbjXJxzSRg4Oo0qGFDM4uEhqqmFy_-_l1T8UxrvgqOo3PGLaT8sqDc2tklBcfVr_0vqVgA6ou6r6CSZKyas</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1539469712</pqid></control><display><type>article</type><title>Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Shukla, P ; Lemley, C.O ; Dubey, N ; Meyer, A.M ; O'Rourke, S.T ; Vonnahme, K.A</creator><creatorcontrib>Shukla, P ; Lemley, C.O ; Dubey, N ; Meyer, A.M ; O'Rourke, S.T ; Vonnahme, K.A</creatorcontrib><description>Abstract Introduction Maternal nutrient restriction and decreased scotophase concentrations of melatonin have been associated with severely compromised pregnancies. We hypothesized that melatonin supplementation in a compromised pregnancy enhances the bradykinin (BK)-induced relaxations of placental arteries thereby ensuring sufficient umbilical blood flow to the developing fetus. Methods Pregnant ewes ( n = 31) were fed an adequate (ADQ) or nutrient restricted (RES) diet supplemented with 5 mg of melatonin (MEL) or without melatonin (CON) from day 50 to 130 of gestation. On day 130 of gestation, the maternal (caruncular; CAR) and fetal (cotyledonary; COT) placental arteries were suspended in organ chambers for isometric tension recording. Results There were no treatment or dietary effects on CAR arteries for any vasoactive agent. However, in COT arteries, MEL ewes were more sensitive ( P < 0.01) to bradykinin-induced relaxation than CON ewes. There was a melatonin by nutritional level interaction ( P < 0.01) with sodium nitroprusside-induced relaxation of COT arteries where CON-RES were more sensitive to sodium nitroprusside compared to CON-ADQ, which was in contrast to when ewes were fed MEL. There was a significant melatonin by nutritional interaction ( P = 0.04) for responsiveness to norepinephrine. The sensitivity of the COT arteries to norepinephrine in CON-RES ewes was decreased compared to CON-ADQ. Melatonin supplementation, regardless of maternal dietary intake, resulted in COT arteries having similar responsiveness to CON-RES ewes. Conclusion An increase in placental vessel sensitivity to bradykinin-induced relaxation may contribute to melatonin-induced increases in umbilical artery blood flow.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2014.04.007</identifier><identifier>PMID: 24816515</identifier><identifier>CODEN: PLACDF</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Angiotensin II - pharmacology ; Animal Nutritional Physiological Phenomena ; Animals ; Arterial relaxation ; Biological and medical sciences ; Bradykinin - pharmacology ; Diet ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Gestation ; Internal Medicine ; Maternal Nutritional Physiological Phenomena ; Melatonin ; Melatonin - administration & dosage ; Melatonin - physiology ; Norepinephrine - pharmacology ; Nutrient restriction ; Obstetrics and Gynecology ; Placenta - blood supply ; Placenta - drug effects ; Placental blood flow ; Placental Circulation - drug effects ; Pregnancy ; Sheep ; Sheep, Domestic ; Vasodilation - drug effects ; Vasodilation - physiology</subject><ispartof>Placenta (Eastbourne), 2014-07, Vol.35 (7), p.461-466</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c400t-160b8b25275bbdd547ce13f4391ce4e1d11366146f018a6efa4b2f420af3227a3</cites><orcidid>0000-0003-2024-7361</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28541295$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24816515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shukla, P</creatorcontrib><creatorcontrib>Lemley, C.O</creatorcontrib><creatorcontrib>Dubey, N</creatorcontrib><creatorcontrib>Meyer, A.M</creatorcontrib><creatorcontrib>O'Rourke, S.T</creatorcontrib><creatorcontrib>Vonnahme, K.A</creatorcontrib><title>Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Abstract Introduction Maternal nutrient restriction and decreased scotophase concentrations of melatonin have been associated with severely compromised pregnancies. We hypothesized that melatonin supplementation in a compromised pregnancy enhances the bradykinin (BK)-induced relaxations of placental arteries thereby ensuring sufficient umbilical blood flow to the developing fetus. Methods Pregnant ewes ( n = 31) were fed an adequate (ADQ) or nutrient restricted (RES) diet supplemented with 5 mg of melatonin (MEL) or without melatonin (CON) from day 50 to 130 of gestation. On day 130 of gestation, the maternal (caruncular; CAR) and fetal (cotyledonary; COT) placental arteries were suspended in organ chambers for isometric tension recording. Results There were no treatment or dietary effects on CAR arteries for any vasoactive agent. However, in COT arteries, MEL ewes were more sensitive ( P < 0.01) to bradykinin-induced relaxation than CON ewes. There was a melatonin by nutritional level interaction ( P < 0.01) with sodium nitroprusside-induced relaxation of COT arteries where CON-RES were more sensitive to sodium nitroprusside compared to CON-ADQ, which was in contrast to when ewes were fed MEL. There was a significant melatonin by nutritional interaction ( P = 0.04) for responsiveness to norepinephrine. The sensitivity of the COT arteries to norepinephrine in CON-RES ewes was decreased compared to CON-ADQ. Melatonin supplementation, regardless of maternal dietary intake, resulted in COT arteries having similar responsiveness to CON-RES ewes. Conclusion An increase in placental vessel sensitivity to bradykinin-induced relaxation may contribute to melatonin-induced increases in umbilical artery blood flow.</description><subject>Angiotensin II - pharmacology</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Arterial relaxation</subject><subject>Biological and medical sciences</subject><subject>Bradykinin - pharmacology</subject><subject>Diet</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestation</subject><subject>Internal Medicine</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Melatonin</subject><subject>Melatonin - administration & dosage</subject><subject>Melatonin - physiology</subject><subject>Norepinephrine - pharmacology</subject><subject>Nutrient restriction</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta - blood supply</subject><subject>Placenta - drug effects</subject><subject>Placental blood flow</subject><subject>Placental Circulation - drug effects</subject><subject>Pregnancy</subject><subject>Sheep</subject><subject>Sheep, Domestic</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFUl2r1DAQLaJ416t_4ZIXwZeumTRtty-iXK4fcMEH9Tmk6USypmlN0oX9N_5Up-6uoi_CkAyZM2c-ToriBvgWODQv99vZa4Mh663gILecjLcPig3UlSgr4OJhsaFAVUrO5VXxJKU957yTIB4XV0LuoKmh3hQ_7qxFk9lk2agzxqA9C0uOjqhZxESeyW4KTIeBjeh1noILLC3z7HFc6_-K2jiNbHQDyxMjDLKvlHoKkR10MovXkQg1sR1cPv5VcOW2mMm7DEVvkYIO09PikdU-4bPzfV18eXv3-fZ9ef_x3YfbN_eloQFzCQ3vd72oRVv3_TDUsjUIlZVVBwYlwgBQNQ3IxnLY6Qatlr2wUnBtKyFaXV0XL068c5y-L9S9Gl0y6L0OOC1J0V472XQtCII2J6iJU0oRrZqjG3U8KuBqVUft1WUQtaqjOBlvKfHmXGPpRxx-p13kIMDzM4A2pr2NOhiX_uB2NenXrbjXJxzSRg4Oo0qGFDM4uEhqqmFy_-_l1T8UxrvgqOo3PGLaT8sqDc2tklBcfVr_0vqVgA6ou6r6CSZKyas</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Shukla, P</creator><creator>Lemley, C.O</creator><creator>Dubey, N</creator><creator>Meyer, A.M</creator><creator>O'Rourke, S.T</creator><creator>Vonnahme, K.A</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2024-7361</orcidid></search><sort><creationdate>20140701</creationdate><title>Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries</title><author>Shukla, P ; Lemley, C.O ; Dubey, N ; Meyer, A.M ; O'Rourke, S.T ; Vonnahme, K.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-160b8b25275bbdd547ce13f4391ce4e1d11366146f018a6efa4b2f420af3227a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Angiotensin II - pharmacology</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Arterial relaxation</topic><topic>Biological and medical sciences</topic><topic>Bradykinin - pharmacology</topic><topic>Diet</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestation</topic><topic>Internal Medicine</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>Melatonin</topic><topic>Melatonin - administration & dosage</topic><topic>Melatonin - physiology</topic><topic>Norepinephrine - pharmacology</topic><topic>Nutrient restriction</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta - blood supply</topic><topic>Placenta - drug effects</topic><topic>Placental blood flow</topic><topic>Placental Circulation - drug effects</topic><topic>Pregnancy</topic><topic>Sheep</topic><topic>Sheep, Domestic</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shukla, P</creatorcontrib><creatorcontrib>Lemley, C.O</creatorcontrib><creatorcontrib>Dubey, N</creatorcontrib><creatorcontrib>Meyer, A.M</creatorcontrib><creatorcontrib>O'Rourke, S.T</creatorcontrib><creatorcontrib>Vonnahme, K.A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shukla, P</au><au>Lemley, C.O</au><au>Dubey, N</au><au>Meyer, A.M</au><au>O'Rourke, S.T</au><au>Vonnahme, K.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>35</volume><issue>7</issue><spage>461</spage><epage>466</epage><pages>461-466</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><coden>PLACDF</coden><abstract>Abstract Introduction Maternal nutrient restriction and decreased scotophase concentrations of melatonin have been associated with severely compromised pregnancies. We hypothesized that melatonin supplementation in a compromised pregnancy enhances the bradykinin (BK)-induced relaxations of placental arteries thereby ensuring sufficient umbilical blood flow to the developing fetus. Methods Pregnant ewes ( n = 31) were fed an adequate (ADQ) or nutrient restricted (RES) diet supplemented with 5 mg of melatonin (MEL) or without melatonin (CON) from day 50 to 130 of gestation. On day 130 of gestation, the maternal (caruncular; CAR) and fetal (cotyledonary; COT) placental arteries were suspended in organ chambers for isometric tension recording. Results There were no treatment or dietary effects on CAR arteries for any vasoactive agent. However, in COT arteries, MEL ewes were more sensitive ( P < 0.01) to bradykinin-induced relaxation than CON ewes. There was a melatonin by nutritional level interaction ( P < 0.01) with sodium nitroprusside-induced relaxation of COT arteries where CON-RES were more sensitive to sodium nitroprusside compared to CON-ADQ, which was in contrast to when ewes were fed MEL. There was a significant melatonin by nutritional interaction ( P = 0.04) for responsiveness to norepinephrine. The sensitivity of the COT arteries to norepinephrine in CON-RES ewes was decreased compared to CON-ADQ. Melatonin supplementation, regardless of maternal dietary intake, resulted in COT arteries having similar responsiveness to CON-RES ewes. Conclusion An increase in placental vessel sensitivity to bradykinin-induced relaxation may contribute to melatonin-induced increases in umbilical artery blood flow.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24816515</pmid><doi>10.1016/j.placenta.2014.04.007</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2024-7361</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0143-4004 |
| ispartof | Placenta (Eastbourne), 2014-07, Vol.35 (7), p.461-466 |
| issn | 0143-4004 1532-3102 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1539469712 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Angiotensin II - pharmacology Animal Nutritional Physiological Phenomena Animals Arterial relaxation Biological and medical sciences Bradykinin - pharmacology Diet Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Gestation Internal Medicine Maternal Nutritional Physiological Phenomena Melatonin Melatonin - administration & dosage Melatonin - physiology Norepinephrine - pharmacology Nutrient restriction Obstetrics and Gynecology Placenta - blood supply Placenta - drug effects Placental blood flow Placental Circulation - drug effects Pregnancy Sheep Sheep, Domestic Vasodilation - drug effects Vasodilation - physiology |
| title | Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T21%3A36%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20maternal%20nutrient%20restriction%20and%20melatonin%20supplementation%20from%20mid%20to%20late%20gestation%20on%20vascular%20reactivity%20of%20maternal%20and%20fetal%20placental%20arteries&rft.jtitle=Placenta%20(Eastbourne)&rft.au=Shukla,%20P&rft.date=2014-07-01&rft.volume=35&rft.issue=7&rft.spage=461&rft.epage=466&rft.pages=461-466&rft.issn=0143-4004&rft.eissn=1532-3102&rft.coden=PLACDF&rft_id=info:doi/10.1016/j.placenta.2014.04.007&rft_dat=%3Cproquest_cross%3E1539469712%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c400t-160b8b25275bbdd547ce13f4391ce4e1d11366146f018a6efa4b2f420af3227a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1539469712&rft_id=info:pmid/24816515&rfr_iscdi=true |