ZnO-Supported Pd Nanoparticle-Catalyzed Ligand- and Additive-Free Cyanation of Unactivated Aryl Halides Using K4[Fe(CN)6]

The use of a new ZnO-supported palladium(0) nanoparticle catalyst for the cyanation of aryl halides using a relatively benign cyanide source, K4[Fe(CN)6], is described. This catalyst has been applied for the efficient cyanation of a variety of functionalized aryl bromides and activated aryl chloride...

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Bibliographic Details
Published in:Journal of organic chemistry 2014-06, Vol.79 (12), p.5875-5879
Main Authors: Chatterjee, Tanmay, Dey, Raju, Ranu, Brindaban C
Format: Article
Language:English
Subjects:
Catalysis
Ferricyanides - chemistry
Halogens - chemistry
Ligands
Molecular Structure
Nanoparticles - chemistry
Nitriles - chemistry
Palladium - chemistry
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Description
Summary:The use of a new ZnO-supported palladium(0) nanoparticle catalyst for the cyanation of aryl halides using a relatively benign cyanide source, K4[Fe(CN)6], is described. This catalyst has been applied for the efficient cyanation of a variety of functionalized aryl bromides and activated aryl chlorides. This process circumvents the need for an additive and a ligand for the reaction and offers the advantages of high product yields, low catalyst loading (0.2 mol % Pd), and recyclability of the catalyst.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo500820q