Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels

Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue with induced...

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Bibliographic Details
Published in:Pharmacological reports 2014-08, Vol.66 (4), p.647-652
Main Authors: Demiryilmaz, Ismail, Turan, Mehmet Ibrahim, Kisaoglu, Abdullah, Gulapoglu, Mine, Yilmaz, Ismayil, Suleyman, Halis
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Cyclooxygenase 1 - metabolism
Cyclooxygenase 2 - metabolism
Cyclooxygenase 2 Inhibitors - administration & dosage
Cyclooxygenase 2 Inhibitors - pharmacology
Cyclooxygenase 2 Inhibitors - therapeutic use
DNA Damage - genetics
Dose-Response Relationship, Drug
Drug Safety and Pharmacovigilance
Lipid Peroxidation - drug effects
Liver
Liver - blood supply
Liver - drug effects
Liver - enzymology
Liver Function Tests
Male
Mutation
Nimesulide
Original Research Article
Oxidant/antioxidant
Pharmacotherapy
Pharmacy
Rat
Rats, Wistar
Reperfusion Injury - enzymology
Reperfusion Injury - genetics
Reperfusion Injury - metabolism
Reperfusion Injury - prevention & control
Sulfonamides - administration & dosage
Sulfonamides - pharmacology
Sulfonamides - therapeutic use
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Summary:Nimesulide is a pharmacological agent and selective COX-2 inhibitor. It has anti-inflammatory, analgesic and antipyretic properties. The purpose of this study was to investigate the effect of nimesulide on oxidant/antioxidant, DNA mutation and COX-1/COX-2 activities in rat liver tissue with induced ischemia/reperfusion (I/R). Before the experiment, rats were divided into four groups; liver ischemia/reperfusion (LIR), 50mg/kg nimesulide+liver ischemia/reperfusion (NLIR50), 100mg/kg nimesulide+liver ischemia/reperfusion (NLIR100) and a control group to be given a sham operation (SG). Malondialdehyde (MDA), total glutathione (GSH) levels and myeloperoxidase (MPO), COX-1/COX-2 enzyme activities and DNA damage product level results from liver tissues and serum AST and ALT levels were determined. The data obtained were compared with the results from the liver ischemia/reperfusion and sham operation groups. MDA levels, MPO and COX-2 activities and products of DNA injury were significantly lower in the groups given nimesulide, and particularly the NLIR100 group, compared to the LIR group (p
ISSN:1734-1140
2299-5684
DOI:10.1016/j.pharep.2014.02.015