The impact of donor naive and memory T cell subsets on patient outcome following allogeneic stem cell transplantation: relationship between infused donor CD4+/CCR7+ T cell subsets and acute graft-versus-host disease

In a previous prospective study on 62 patients who underwent an HLA-matched allogeneic stem cell transplantation, we have observed that proportion of donor-derived CCR7(+)/CD4(+) T cells in the graft provided a predictive indicator of acute GVHD without interfering on chronic GVHD and relapse rate....

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Bibliographic Details
Published in:Pathologie biologie (Paris) 2014-06, Vol.62 (3), p.123-128
Main Authors: Choufi, B, Thiant, S, Trauet, J, Cliquennois, M, Cherrel, M, Boulanger, F, Coiteux, V, Magro, L, Labalette, M, Yakoub-Agha, I
Format: Article
Language:fre
Subjects:
Acute Disease
Adolescent
Adult
Aged
Allografts - immunology
Bone Marrow Transplantation
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - transplantation
Child
Female
Graft Survival - immunology
Graft vs Host Disease - immunology
Hematologic Neoplasms - therapy
Humans
Immunologic Memory
Immunophenotyping
Living Donors
Lymphocyte Depletion
Male
Middle Aged
Peripheral Blood Stem Cell Transplantation
Prospective Studies
Receptors, CCR7 - analysis
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - transplantation
Treatment Outcome
Young Adult
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Summary:In a previous prospective study on 62 patients who underwent an HLA-matched allogeneic stem cell transplantation, we have observed that proportion of donor-derived CCR7(+)/CD4(+) T cells in the graft provided a predictive indicator of acute GVHD without interfering on chronic GVHD and relapse rate. Here we present our results on a confirmatory cohort of 137 consecutive patients. Indeed patients who received more than 76% of CCR7(+)/CD4(+) T cells in the graft developed more often acute GVHD be it of low or high grade than those who did not. Determination of the CCR7(+)/CCR7(neg) ratio of CD4(+) T cells in the graft provides a predictive indicator of acute GVHD and could help to define strategies of partial selective T cell depleted transplantation.
ISSN:1768-3114
DOI:10.1016/j.patbio.2014.02.013