Ceftazidime: in-vitro Antibacterial Activity and Susceptibility to beta -Lactamases Compared With That of Cefotaxime, Moxalactam and Other beta -Lactam Antibiotics

The in-vitro antibacterial activity of ceftazidime was assessed against recent clinical isolates of common bacteria and also against reference strains that produced known beta -lactamases. The compound was active, though less so than cephaloridine against staphylococci and streptococci with MICs mos...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1981-01, Vol.8, p.no. Sul. B-no. Sul. B
Main Authors: Phillips, I, Warren, C, Shannon, K, King, A, Hanslo, D
Format: Article
Language:English
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Summary:The in-vitro antibacterial activity of ceftazidime was assessed against recent clinical isolates of common bacteria and also against reference strains that produced known beta -lactamases. The compound was active, though less so than cephaloridine against staphylococci and streptococci with MICs mostly 0 multiplied by 12-2 mg/l for streptococci and 8 mg/l for staphylococci, but enterococci (MICs greater than or equal to 64 mg/l) and methicillin-resistant staphylococci (MICs 16-32 mg/l) were resistant. Penicillin-resistant pneumococci (MICs 2-4 mg/l) were much less sensitive than other pneumococci (MICs 0 multiplied by 12-0 multiplied by 25 mg/l). Ceftazidime was also active, but slightly less so than cefotaxime or moxalactam, against enterobacteria (MICs mostly 0 multiplied by 12-0 multiplied by 25 mg/l). Its activity was also inferior to that of cefotaxime against Neisseria gonorrhoeae (MICs mostly 0 multiplied by 03-0 multiplied by 06 mg/l) and Haemophilus influenzae (MICs mostly 0 multiplied by 06-0 multiplied by 25 mg/l).
ISSN:0305-7453