Development and Function of Dendritic Cell Subsets

Classical dendritic cells (cDCs) form a critical interface between innate and adaptive immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of pathogen challenges and cancer. They translate the latter for T cells into peptide form. Moreover, cDCs provide additional critica...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2014-05, Vol.40 (5), p.642-656
Main Authors: Mildner, Alexander, Jung, Steffen
Format: Article
Language:English
Subjects:
Adaptive Immunity - immunology
Animals
Antigen Presentation - immunology
Chemokines
Dendritic Cells - immunology
Immune system
Immunity, Innate - immunology
Lymphocytes
Lymphoid Tissue - cytology
Lymphoid Tissue - immunology
Mice
Migration
T cell receptors
T-Lymphocytes, Regulatory - immunology
Viral infections
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Summary:Classical dendritic cells (cDCs) form a critical interface between innate and adaptive immunity. As myeloid immune cell sentinels, cDCs are specialized in the sensing of pathogen challenges and cancer. They translate the latter for T cells into peptide form. Moreover, cDCs provide additional critical information on the original antigen context to trigger a diverse spectrum of appropriate protective responses. Here we review recent progress in our understanding of cDC subsets in mice. We will discuss cDC subset ontogeny and transcription factor dependencies, as well as emerging functional specializations within the cDC compartment in lymphoid and nonlymphoid tissues.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2014.04.016