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Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels

Highlights • We introduce a new term/syndrome osteosarcopenic obesity. • The term explains coexistence of deteriorated bone and muscle in the presence of obesity. • Interactions of three tissues, considering their endocrine features are presented. • Stem cell commitment into each tissue and causes o...

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Bibliographic Details
Published in:Ageing research reviews 2014-05, Vol.15, p.51-60
Main Authors: Ilich, Jasminka Z, Kelly, Owen J, Inglis, Julia E, Panton, Lynn B, Duque, Gustavo, Ormsbee, Michael J
Format: Article
Language:English
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Summary:Highlights • We introduce a new term/syndrome osteosarcopenic obesity. • The term explains coexistence of deteriorated bone and muscle in the presence of obesity. • Interactions of three tissues, considering their endocrine features are presented. • Stem cell commitment into each tissue and causes of its deregulation are presented. • Identification and possible diagnosis of osteosarcopenic obesity are discussed.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2014.02.007