Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta)

Two aged female rhesus macaques (Macaca mulatta) presented with weight loss and intermittent inappetence. The signalment and constellation of clinical signs led clinicians to suspect the presence of intestinal adenocarcinoma. Because of each animal's advanced age and inconclusive radiographic f...

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Bibliographic Details
Published in:Comparative medicine 2014-06, Vol.64 (3), p.211-220
Main Authors: Caporizzo, Debra J, Kwiatkowski, Anna E, Chen, Ming-Kai, Beck, Amanda P, Booth, Carmen J, Zeiss, Caroline, Smith, Peter C, Carlson Scholz, Jodi A, Wilson, Steven R
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - veterinary
Animals
Female
Fluorodeoxyglucose F18
Intestinal Neoplasms - diagnosis
Intestinal Neoplasms - veterinary
Macaca mulatta
Monkey Diseases - diagnosis
Positron-Emission Tomography - methods
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Summary:Two aged female rhesus macaques (Macaca mulatta) presented with weight loss and intermittent inappetence. The signalment and constellation of clinical signs led clinicians to suspect the presence of intestinal adenocarcinoma. Because of each animal's advanced age and inconclusive radiographic findings, a noninvasive diagnostic tool was preferred over exploratory laparotomy to assist in determining a diagnosis. Consequently, 2-[(18)F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography-CT (FDG-PET-CT) was chosen to aid in confirming a suspicion of gastrointestinal adenocarcinoma in both animals. FDG is a glucose analogue labeled with fluorine-18 and is taken up by highly metabolically active cells, as observed in many cancers. Tomography revealed an annular constriction of the small intestine with focal FDG uptake in one animal, and an FDG avid transmural mass in the ascending colon of the second animal. Necropsy later confirmed both sites to be adenocarcinomas. This report supports the use of FDG-PET-CT as an adjunct to conventional radiography in the diagnosis of intestinal adenocarcinoma in nonhuman primates.
ISSN:1532-0820