NFAT Isoforms Regulate Muscle Fiber Type Transition without Altering CaN during Aerobic Training

Abstract The purpose of this study was to determine whether the aerobic training-induced fiber-type transition in different muscles is associated with alterations in NFAT isoforms gene expression. We hypothesized that the aerobic training-induced fiber-type transition would be mediated by NFATc1–c3...

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Bibliographic Details
Published in:International journal of sports medicine 2013-10, Vol.34 (10), p.861-867
Main Authors: Vechetti-Júnior, I. J., Aguiar, A. F., de Souza, R.W. A., Almeida, F.L. A., de Almeida Dias, H. B., de Aguiar Silva, M. A., Carani, F. R., Ferraresso, R.L. P., Carvalho, R. F., Dal-Pai-Silva, M.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomarkers - metabolism
Calcineurin - metabolism
Fundamental and applied biological sciences. Psychology
Human physiology applied to population studies and life conditions. Human ecophysiology
Male
Medical sciences
Muscle Fibers, Fast-Twitch - metabolism
Muscle Fibers, Slow-Twitch - metabolism
Myosin Heavy Chains - metabolism
NFATC Transcription Factors - metabolism
Physical Endurance - physiology
Physiology & Biochemistry
Protein Isoforms - metabolism
Random Allocation
Rats
Rats, Wistar
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Swimming - physiology
Transcription Factors - metabolism
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Summary:Abstract The purpose of this study was to determine whether the aerobic training-induced fiber-type transition in different muscles is associated with alterations in NFAT isoforms gene expression. We hypothesized that the aerobic training-induced fiber-type transition would be mediated by NFATc1–c3 isoforms without altering the CaN expression. Male Wistar rats (80 days old) were divided into a trained group (T; n =8) that underwent an 8-wk swimming endurance training program (5 days/week) and a control group (C; n =8). After the experimental period, the animals were sacrificed, and the soleus (SOL) and plantaris (PL) muscles were collected for morphometrical, histochemical and molecular analyses. Aerobic training induced a type I-to-type IIA fiber transition in the SOL muscle and a type IIB-to-type IIA fiber transition in the PL muscle, which were concomitant with a significant (p
ISSN:0172-4622
1439-3964
DOI:10.1055/s-0032-1331758