Curcumin Ameliorates Streptozotocin-Induced Heart Injury in Rats

• Published in: Journal of biochemical and molecular toxicology 2014-06, Vol.28 (6), p.263-270
• Main Authors: Abo-Salem, Osama M., Harisa, Gamaleldin I., Ali, Tarek M., El-Sayed, El-Sayed M., Abou-Elnour, Fatma M.
• Format: Article
• Language: English
• Subjects: Animal care; Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Blood Glucose; Cholesterol; Curcumin; Curcumin - pharmacology; Curcumin - therapeutic use; Cytokines; Diabetes; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - complications; Glutathione - metabolism; Glyburide - pharmacology; Glyburide - therapeutic use; Heart Failure - blood; Heart Failure - etiology; Heart Failure - prevention & control; Heart Injury; Inflammation Mediators - blood; Interleukin-6 - blood; L-Lactate Dehydrogenase - blood; Low density lipoprotein; Male; Myocardium - metabolism; Myocardium - pathology; Nitric Oxide - blood; Organ Size - drug effects; Oxidative Stress; Rats, Wistar; Rodents; Streptozocin; STZ; Tumor Necrosis Factor-alpha - blood
• ISSN: 1095-6670; 1099-0461
• DOI: 10.1002/jbt.21562

ABSTRACT Heart failure (HF) is one of diabetic complications. This work was designed to investigate the possible modulatory effect of curcumin against streptozotocin‐induced diabetes and consequently HF in rats. Rats were divided into control, vehicle‐treated, curcumin‐treated, diabetic‐untreated, diabetic curcumin–treated, and diabetic glibenclamide–treated groups. Animal treatment was started 5 days after induction of diabetes and extended for 6 weeks. Diabetic rats showed significant increase in serum glucose, triglycerides, total cholesterol, low‐density lipoprotein‐cholesterol, very low density lipoprotein‐cholesterol, nitric oxide, lactate dehydrogenase, cardiac malondialdehyde, plasma levels of interleukin‐6, and tumor necrosis factor‐alpha, and also showed marked decrease in serum high‐density lipoprotein‐cholesterol, cardiac reduced glutathione, and cardiac antioxidant enzymes (catalase, superoxide dismutase, and glutathione‐S‐transferase). However, curcumin or glibenclamide treatment significantly mitigated such changes. In conclusion, curcumin has a beneficial therapeutic effect in diabetes‐induced HF, an effect that might be attributable to its antioxidant and suppressive activity on cytokines.