Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment

Summary Objectives IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB). Methods In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with act...

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Bibliographic Details
Published in:The Journal of infection 2014-03, Vol.68 (3), p.252-258
Main Authors: Hong, Ji Young, Lee, Hye Jon, Kim, Song Yee, Chung, Kyung Soo, Kim, Eun Young, Jung, Ji Ye, Park, Moo Suk, Kim, Young Sam, Kim, Se Kyu, Chang, Joon, Cho, Sang-Nae, Kang, Young Ae
Format: Article
Language:English
Subjects:
Adult
Aged
Bacterial diseases
Biological and medical sciences
Biomarkers - blood
Chemokine CXCL10 - blood
Drug Monitoring
Female
General aspects
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Interferon-gamma - blood
IP-10
Longitudinal Studies
Male
Medical sciences
Middle Aged
Monitoring
Mycobacterium
Tuberculosis
Tuberculosis - blood
Tuberculosis - diagnosis
Tuberculosis - drug therapy
Tuberculosis - immunology
Tuberculosis and atypical mycobacterial infections
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Summary:Summary Objectives IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB). Methods In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with active TB. Results Significant changes in concentration between the time of diagnosis and the completion of therapy were observed for serum IP-10 ( P  
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2013.09.033