Risk factor analysis of non‐Hodgkin lymphoma‐associated haemophagocytic syndromes: a multicentre study

Summary Haemophagocytic syndrome is often associated with malignant lymphoma; however, few studies have examined lymphoma‐associated haemophagocytic syndrome (LAHS). A total of 1239 patients with non‐Hodgkin lymphoma were analysed at 12 institutions in Hokkaido prefecture between January 2007 and De...

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Bibliographic Details
Published in:British journal of haematology 2014-06, Vol.165 (6), p.786-792
Main Authors: Sano, Hirozumi, Kobayashi, Ryoji, Tanaka, Junji, Hashino, Satoshi, Ota, Shuichi, Torimoto, Yoshihiro, Kakinoki, Yasutaka, Yamamoto, Satoshi, Kurosawa, Mitsutoshi, Hatakeyama, Naoki, Haseyama, Yoshihito, Sakai, Hajime, Sato, Kazuya, Fukuhara, Takashi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
B‐cell lymphoma
Child
Child, Preschool
Female
Hematologic and hematopoietic diseases
Humans
Incidence
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphohistiocytosis, Hemophagocytic - diagnosis
Lymphohistiocytosis, Hemophagocytic - epidemiology
Lymphohistiocytosis, Hemophagocytic - etiology
Lymphoma, Non-Hodgkin - complications
Lymphoma, Non-Hodgkin - diagnosis
lymphoma‐associated haemophagocytic syndrome
Male
Medical sciences
Middle Aged
Mortality
Prognosis
prognostic factor
risk factor
Risk Factors
T/NK cell lymphoma
Tumors
Young Adult
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Summary:Summary Haemophagocytic syndrome is often associated with malignant lymphoma; however, few studies have examined lymphoma‐associated haemophagocytic syndrome (LAHS). A total of 1239 patients with non‐Hodgkin lymphoma were analysed at 12 institutions in Hokkaido prefecture between January 2007 and December 2011 to assess the incidence, prognosis and risk factors of LAHS. The cumulative incidence rate of LAHS was 2·8% (35/1239). Overall survival (OS) in patients with LAHS was significantly inferior to those without LAHS (3‐year OS: 35·6 vs. 59·0% respectively, P 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.12823