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Larvicidal activity of lignans from Phryma leptostachya L. against Culex pipiens pallens
The larvicidal activity of crude petroleum ether, ethyl acetate, and methanol extracts of the whole plants of Phryma leptostachya L. was assayed for its toxicity against the early fourth instar larvae of Culex pipiens pallens . The larval mortality was observed after 24 h of exposure. Among three so...
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| Published in: | Parasitology research (1987) 2012-03, Vol.110 (3), p.1079-1084 |
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| container_title | Parasitology research (1987) |
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| creator | Xiao, Xin-min Hu, Zhao-nong Shi, Bao-jun Wei, Shao-peng Wu, Wen-jun |
| description | The larvicidal activity of crude petroleum ether, ethyl acetate, and methanol extracts of the whole plants of
Phryma leptostachya
L. was assayed for its toxicity against the early fourth instar larvae of
Culex pipiens pallens
. The larval mortality was observed after 24 h of exposure. Among three solvent extracts from
Phyrma leptostachya
L., the petroleum ether extract exhibited the best larvicidal activity. The corresponding LC
50
values of petroleum ether, ethyl acetate, and methanol extracts were 3.23, 5.23, and 61.86 ppm against the early fourth instar larvae of
Culex pipiens pallens
. The petroleum ether extract was successively subjected to column chromatography and preparative high performance liquid chromatography, and yielded the three lignans, phrymarolin-I, haedoxane A, and haedoxane E, which were isolated and identified as new mosquito larvicidal compounds. Phrymarolin-I, haedoxane A, and haedoxane E showed high larvicidal activity, for which the lethal doses LC
50
were estimated at 1.21, 0.025, and 0.15 ppm against the early fourth instar larvae of
Culex pipiens pallens
, respectively. The structures were elucidated by analyses of IR, UV, MS, and NMR spectral data. This is the first report on the mosquito larvicidal activity of the three compounds, phrymarolin-I, haedoxane A, and haedoxane E from
Phyrma leptostachya
L. |
| doi_str_mv | 10.1007/s00436-011-2591-1 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1540226337</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A306249465</galeid><sourcerecordid>A306249465</sourcerecordid><originalsourceid>FETCH-LOGICAL-c539t-296f25e37688a89686b923d8cb7ca072d949a4f265ff469ef087f3b0b5dfd6853</originalsourceid><addsrcrecordid>eNp9kUuLFDEURoMoTjv6A9xIQAQ31ZN3VZZD4wsaxsUI7sKtVNKTIfUwqRrsf2-aahVBhixuyD3fTchB6DUlW0pIfZUJEVxVhNKKSU0r-gRtqOCsolrKp2hDdNmXLr9AL3K-J4TWSojn6ILRRjai1hv0fQ_pIdjQQcRg5_AQ5iMePY7hMMCQsU9jj7_epWMPOLppHvMM9u4IeL_FcIAw5Bnvluh-4ilMwZXEBDGW-hI98xCze3Wul-jbxw-3u8_V_ubTl931vrKS67liWnkmHa9V00CjVaNazXjX2La2QGrWaaFBeKak90Jp50lTe96SVna-U43kl-j9OndK44_F5dn0IVsXIwxuXLKhUhDGFOd1Qd-u6AGiM2Hw45zAnnBzzYliQgt1Grj9D1VW5_pgx8H5UM7_CdA1YNOYc3LeTCn0kI6GEnPyZFZPppgwJ0-Glsyb86uXtnfdn8RvMQV4dwYgW4g-wWBD_stJqZRWpHBs5XJpDQeXzP24pKH8-CO3_wIaQqiq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1540226337</pqid></control><display><type>article</type><title>Larvicidal activity of lignans from Phryma leptostachya L. against Culex pipiens pallens</title><source>Springer Nature</source><creator>Xiao, Xin-min ; Hu, Zhao-nong ; Shi, Bao-jun ; Wei, Shao-peng ; Wu, Wen-jun</creator><creatorcontrib>Xiao, Xin-min ; Hu, Zhao-nong ; Shi, Bao-jun ; Wei, Shao-peng ; Wu, Wen-jun</creatorcontrib><description>The larvicidal activity of crude petroleum ether, ethyl acetate, and methanol extracts of the whole plants of
Phryma leptostachya
L. was assayed for its toxicity against the early fourth instar larvae of
Culex pipiens pallens
. The larval mortality was observed after 24 h of exposure. Among three solvent extracts from
Phyrma leptostachya
L., the petroleum ether extract exhibited the best larvicidal activity. The corresponding LC
50
values of petroleum ether, ethyl acetate, and methanol extracts were 3.23, 5.23, and 61.86 ppm against the early fourth instar larvae of
Culex pipiens pallens
. The petroleum ether extract was successively subjected to column chromatography and preparative high performance liquid chromatography, and yielded the three lignans, phrymarolin-I, haedoxane A, and haedoxane E, which were isolated and identified as new mosquito larvicidal compounds. Phrymarolin-I, haedoxane A, and haedoxane E showed high larvicidal activity, for which the lethal doses LC
50
were estimated at 1.21, 0.025, and 0.15 ppm against the early fourth instar larvae of
Culex pipiens pallens
, respectively. The structures were elucidated by analyses of IR, UV, MS, and NMR spectral data. This is the first report on the mosquito larvicidal activity of the three compounds, phrymarolin-I, haedoxane A, and haedoxane E from
Phyrma leptostachya
L.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-011-2591-1</identifier><identifier>PMID: 21858479</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animals ; Benzodioxoles - analysis ; Benzodioxoles - pharmacology ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Control ; Culex - drug effects ; Culex - growth & development ; Culex pipiens pallens ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; Immunology ; Insecticides ; Invertebrates ; Lamiales ; Larva - drug effects ; Lignans - analysis ; Lignans - pharmacology ; Magnoliopsida - chemistry ; Materia medica, Vegetable ; Medical Microbiology ; Microbiology ; Mosquitoes ; Original Paper ; Phryma ; Plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Testing</subject><ispartof>Parasitology research (1987), 2012-03, Vol.110 (3), p.1079-1084</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-296f25e37688a89686b923d8cb7ca072d949a4f265ff469ef087f3b0b5dfd6853</citedby><cites>FETCH-LOGICAL-c539t-296f25e37688a89686b923d8cb7ca072d949a4f265ff469ef087f3b0b5dfd6853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25566960$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21858479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Xin-min</creatorcontrib><creatorcontrib>Hu, Zhao-nong</creatorcontrib><creatorcontrib>Shi, Bao-jun</creatorcontrib><creatorcontrib>Wei, Shao-peng</creatorcontrib><creatorcontrib>Wu, Wen-jun</creatorcontrib><title>Larvicidal activity of lignans from Phryma leptostachya L. against Culex pipiens pallens</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>The larvicidal activity of crude petroleum ether, ethyl acetate, and methanol extracts of the whole plants of
Phryma leptostachya
L. was assayed for its toxicity against the early fourth instar larvae of
Culex pipiens pallens
. The larval mortality was observed after 24 h of exposure. Among three solvent extracts from
Phyrma leptostachya
L., the petroleum ether extract exhibited the best larvicidal activity. The corresponding LC
50
values of petroleum ether, ethyl acetate, and methanol extracts were 3.23, 5.23, and 61.86 ppm against the early fourth instar larvae of
Culex pipiens pallens
. The petroleum ether extract was successively subjected to column chromatography and preparative high performance liquid chromatography, and yielded the three lignans, phrymarolin-I, haedoxane A, and haedoxane E, which were isolated and identified as new mosquito larvicidal compounds. Phrymarolin-I, haedoxane A, and haedoxane E showed high larvicidal activity, for which the lethal doses LC
50
were estimated at 1.21, 0.025, and 0.15 ppm against the early fourth instar larvae of
Culex pipiens pallens
, respectively. The structures were elucidated by analyses of IR, UV, MS, and NMR spectral data. This is the first report on the mosquito larvicidal activity of the three compounds, phrymarolin-I, haedoxane A, and haedoxane E from
Phyrma leptostachya
L.</description><subject>Animals</subject><subject>Benzodioxoles - analysis</subject><subject>Benzodioxoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Control</subject><subject>Culex - drug effects</subject><subject>Culex - growth & development</subject><subject>Culex pipiens pallens</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. Models</subject><subject>Immunology</subject><subject>Insecticides</subject><subject>Invertebrates</subject><subject>Lamiales</subject><subject>Larva - drug effects</subject><subject>Lignans - analysis</subject><subject>Lignans - pharmacology</subject><subject>Magnoliopsida - chemistry</subject><subject>Materia medica, Vegetable</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Mosquitoes</subject><subject>Original Paper</subject><subject>Phryma</subject><subject>Plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Testing</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kUuLFDEURoMoTjv6A9xIQAQ31ZN3VZZD4wsaxsUI7sKtVNKTIfUwqRrsf2-aahVBhixuyD3fTchB6DUlW0pIfZUJEVxVhNKKSU0r-gRtqOCsolrKp2hDdNmXLr9AL3K-J4TWSojn6ILRRjai1hv0fQ_pIdjQQcRg5_AQ5iMePY7hMMCQsU9jj7_epWMPOLppHvMM9u4IeL_FcIAw5Bnvluh-4ilMwZXEBDGW-hI98xCze3Wul-jbxw-3u8_V_ubTl931vrKS67liWnkmHa9V00CjVaNazXjX2La2QGrWaaFBeKak90Jp50lTe96SVna-U43kl-j9OndK44_F5dn0IVsXIwxuXLKhUhDGFOd1Qd-u6AGiM2Hw45zAnnBzzYliQgt1Grj9D1VW5_pgx8H5UM7_CdA1YNOYc3LeTCn0kI6GEnPyZFZPppgwJ0-Glsyb86uXtnfdn8RvMQV4dwYgW4g-wWBD_stJqZRWpHBs5XJpDQeXzP24pKH8-CO3_wIaQqiq</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Xiao, Xin-min</creator><creator>Hu, Zhao-nong</creator><creator>Shi, Bao-jun</creator><creator>Wei, Shao-peng</creator><creator>Wu, Wen-jun</creator><general>Springer-Verlag</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope></search><sort><creationdate>20120301</creationdate><title>Larvicidal activity of lignans from Phryma leptostachya L. against Culex pipiens pallens</title><author>Xiao, Xin-min ; Hu, Zhao-nong ; Shi, Bao-jun ; Wei, Shao-peng ; Wu, Wen-jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-296f25e37688a89686b923d8cb7ca072d949a4f265ff469ef087f3b0b5dfd6853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Benzodioxoles - analysis</topic><topic>Benzodioxoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Control</topic><topic>Culex - drug effects</topic><topic>Culex - growth & development</topic><topic>Culex pipiens pallens</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. Models</topic><topic>Immunology</topic><topic>Insecticides</topic><topic>Invertebrates</topic><topic>Lamiales</topic><topic>Larva - drug effects</topic><topic>Lignans - analysis</topic><topic>Lignans - pharmacology</topic><topic>Magnoliopsida - chemistry</topic><topic>Materia medica, Vegetable</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Mosquitoes</topic><topic>Original Paper</topic><topic>Phryma</topic><topic>Plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Testing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Xin-min</creatorcontrib><creatorcontrib>Hu, Zhao-nong</creatorcontrib><creatorcontrib>Shi, Bao-jun</creatorcontrib><creatorcontrib>Wei, Shao-peng</creatorcontrib><creatorcontrib>Wu, Wen-jun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Xin-min</au><au>Hu, Zhao-nong</au><au>Shi, Bao-jun</au><au>Wei, Shao-peng</au><au>Wu, Wen-jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Larvicidal activity of lignans from Phryma leptostachya L. against Culex pipiens pallens</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>110</volume><issue>3</issue><spage>1079</spage><epage>1084</epage><pages>1079-1084</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><coden>PARREZ</coden><abstract>The larvicidal activity of crude petroleum ether, ethyl acetate, and methanol extracts of the whole plants of
Phryma leptostachya
L. was assayed for its toxicity against the early fourth instar larvae of
Culex pipiens pallens
. The larval mortality was observed after 24 h of exposure. Among three solvent extracts from
Phyrma leptostachya
L., the petroleum ether extract exhibited the best larvicidal activity. The corresponding LC
50
values of petroleum ether, ethyl acetate, and methanol extracts were 3.23, 5.23, and 61.86 ppm against the early fourth instar larvae of
Culex pipiens pallens
. The petroleum ether extract was successively subjected to column chromatography and preparative high performance liquid chromatography, and yielded the three lignans, phrymarolin-I, haedoxane A, and haedoxane E, which were isolated and identified as new mosquito larvicidal compounds. Phrymarolin-I, haedoxane A, and haedoxane E showed high larvicidal activity, for which the lethal doses LC
50
were estimated at 1.21, 0.025, and 0.15 ppm against the early fourth instar larvae of
Culex pipiens pallens
, respectively. The structures were elucidated by analyses of IR, UV, MS, and NMR spectral data. This is the first report on the mosquito larvicidal activity of the three compounds, phrymarolin-I, haedoxane A, and haedoxane E from
Phyrma leptostachya
L.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21858479</pmid><doi>10.1007/s00436-011-2591-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2012-03, Vol.110 (3), p.1079-1084 |
| issn | 0932-0113 1432-1955 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1540226337 |
| source | Springer Nature |
| subjects | Animals Benzodioxoles - analysis Benzodioxoles - pharmacology Biological and medical sciences Biomedical and Life Sciences Biomedicine Control Culex - drug effects Culex - growth & development Culex pipiens pallens Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Immunology Insecticides Invertebrates Lamiales Larva - drug effects Lignans - analysis Lignans - pharmacology Magnoliopsida - chemistry Materia medica, Vegetable Medical Microbiology Microbiology Mosquitoes Original Paper Phryma Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Testing |
| title | Larvicidal activity of lignans from Phryma leptostachya L. against Culex pipiens pallens |
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