Malignant degeneration of multilevel monostotic Paget’s disease involving the thoracic spine: An unusual presentation

Abstract Paget’s disease is the second most common metabolic bone disease after osteoporosis and is characterized by abnormal bone turnover and remodeling that can lead to pain, pathological fracture, bony deformity and nerve compression syndromes. The lumbar region is the most commonly affected sit...

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Published in:Journal of clinical neuroscience 2014-07, Vol.21 (7), p.1254-1256
Main Authors: Tan, Lee A, Kasliwal, Manish K, Harbhajanka, Aparna, Miller, Ira J, Deutsch, Harel
Format: Article
Language:English
Subjects:
Cervical Vertebrae
Female
Humans
Kyphosis - etiology
Kyphosis - pathology
Magnetic Resonance Imaging
Malignant degeneration
Middle Aged
Neurology
Osteitis Deformans - complications
Osteitis Deformans - pathology
Paget’s disease
Sarcomatous transformation
Spine
Spine - pathology
Tomography Scanners, X-Ray Computed
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creator Tan, Lee A
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description Abstract Paget’s disease is the second most common metabolic bone disease after osteoporosis and is characterized by abnormal bone turnover and remodeling that can lead to pain, pathological fracture, bony deformity and nerve compression syndromes. The lumbar region is the most commonly affected site within the spine followed by the thoracic and cervical spine. Even though the spine is affected very commonly in Paget’s disease, malignant degeneration is exceptionally rare. Multilevel monostotic spine involvement due to Paget’s disease is very uncommon. An unusual clinico-radiological manifestation of multilevel thoracic Paget’s disease with sarcomatous degeneration presenting as a neurosurgical emergency is reported with a pertinent review of the literature.
doi_str_mv 10.1016/j.jocn.2013.11.003
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source ScienceDirect Journals
subjects Cervical Vertebrae
Female
Humans
Kyphosis - etiology
Kyphosis - pathology
Magnetic Resonance Imaging
Malignant degeneration
Middle Aged
Neurology
Osteitis Deformans - complications
Osteitis Deformans - pathology
Paget’s disease
Sarcomatous transformation
Spine
Spine - pathology
Tomography Scanners, X-Ray Computed
title Malignant degeneration of multilevel monostotic Paget’s disease involving the thoracic spine: An unusual presentation
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