Why have clinical trials in sepsis failed?

Highlights • The biology of sepsis is complex and not specific to infection. • Clinical criteria do not adequately delineate patients who will benefit from specific therapies. • Stratification systems are needed to guide optimal treatment decisions. • Success in developing new treatments will necess...

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Bibliographic Details
Published in:Trends in molecular medicine 2014-04, Vol.20 (4), p.195-203
Main Author: Marshall, John C
Format: Article
Language:English
Subjects:
adjuvant therapy
Animals
biologic response modifier
clinical trials
Clinical Trials as Topic
Drug Evaluation, Preclinical
Humans
Immunity, Innate - drug effects
Immunologic Factors - therapeutic use
innate immunity
intensive care
Pathology
sepsis
Sepsis - drug therapy
Sepsis - epidemiology
Sepsis - immunology
Sepsis - microbiology
septic shock
staging
Treatment Outcome
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Summary:Highlights • The biology of sepsis is complex and not specific to infection. • Clinical criteria do not adequately delineate patients who will benefit from specific therapies. • Stratification systems are needed to guide optimal treatment decisions. • Success in developing new treatments will necessitate new collaborative research models.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2014.01.007