Bioimpedance phase angle predicts muscle function, quality of life and clinical outcome in maintenance hemodialysis patients

• Published in: European journal of clinical nutrition 2014-06, Vol.68 (6), p.683-689
• Main Authors: Beberashvili, I, Azar, A, Sinuani, I, Shapiro, G, Feldman, L, Stav, K, Sandbank, J, Averbukh, Z
• Format: Article
• Language: English
• Subjects: 692/700/1750; 692/700/2814; 692/700/565/1950/1544; 692/700/784; Activities of Daily Living; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Cardiovascular diseases; Cardiovascular Diseases - mortality; Cause of Death; Clinical Nutrition; Clinical outcomes; Confidence intervals; Electric Impedance; Emergency and intensive care: renal failure. Dialysis management; Epidemiology; Feeding. Feeding behavior; Female; Females; Fundamental and applied biological sciences. Psychology; Hand Strength; Health aspects; Health risks; Health Status; Hemodialysis; Hospitalization; Humans; Impedance, Bioelectric; Inflammation - complications; Inflammation - diagnosis; Inflammation - physiopathology; Intensive care medicine; Internal Medicine; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - therapy; Maintenance; Male; Malnutrition; Malnutrition - complications; Malnutrition - diagnosis; Malnutrition - physiopathology; Measurement; Medical sciences; Medicine; Medicine & Public Health; Mental Health; Metabolic Diseases; Middle Aged; Morbidity; Mortality; Mortality risk; Muscle function; Muscle strength; Muscle, Skeletal - physiology; Muscles; Muscular system; Nutrition; Nutritional status; Nutritional Status - physiology; Observational studies; original-article; Patients; Phase shift; Physiological research; Prospective Studies; Public Health; Quality of Life; Renal Dialysis; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2014.67

Background/Objectives: The association of bioimpedance phase angle (PA), as a measure of nutritional status, with muscle function, health-related quality of life (QoL) and subsequent clinical outcomes in maintenance hemodialysis (MHD) patients. Subjects/Methods: A 2-year prospective observational study on 250 MHD outpatients (36.8% women) with a mean age of 68.7±13.6 years. Prospective all-cause and cardiovascular (CV) hospitalization and mortality, malnutrition-inflammation score (MIS), handgrip strength (HGS), bioimpedance and short form 36 (SF-36) QoL scores were the study’s measurements. Results: Across the three PA tertile groups, HGS was incrementally higher in the higher PA tertiles ( P